VDR基因多态性与宁夏回汉族白癜风患者的相关性研究

摘要

目的 研究VDR基因FokI、BsmI位点与宁夏地区回汉族白癜风患者遗传易感性的关系.方法 应用PCR-RFLP技术进行了宁夏回汉族白癜风患者的VDR基因FokI、BsmI位点频率分布的检测.结果 FokI位点的基因型和等位基因的分布频率在宁夏回汉族白癜风患者和对照组中均无统计学意义.BsmI位点Bb基因型的频率分布在宁夏回族白癜风组和回族健康对照组有显著性差异(P为0.033) ;而且Bb基因型的频率在宁夏白癜风患者组和对照组组中也有统计学意义(P值为0.036).结论 VDR 基因BsmI (rs:1544410) 位点可能是宁夏地区尤其是回族人群中白癜风发病的保护因子.%Objective To evaluate the assoriation of the polymorphism of VDR gene FokI and BsmI sites and the gr netir susrrptibility of Hui and Han cthnic vitiligo patiants in XingXia. Methods Polymarase chain relation scquancc rc strirtion fragment length polymorphism (PCR RFLP ) was used to analyzc the distribution of allles and genotypes of the Fold .mel BsmT sites of the VDR gene among Hui and Han cthnir vitiligo patients in Xingxin. Results There was no smtistirally signifirant rliffercncc in the frequencic.s of VDR FokI genotypes and alleles between the vitiligo patients and healthy controls in Han and Hui nationality (P>0.05). There was statistically signifirant diffcrenre in the frequcncies of Bb genotypes of VDR BsmT site between Hui ethnir vitiligo paticnts mel Hui ethnir healthy rontrols in XingXia (P - 0. 033) , and also between vitiligo patients mel healthy rontrols in XingXia. (P -0.026). Conclusion The Bsm I ( rs: 1544410) site of the VDR gene was likely the proteet factor in the pathogrncsis of vitiligo among XingXia population, especially Hui ethnir.