妊娠高血压综合征患者尿转铁蛋白和血清胱抑素C水平分析

摘要

目的：探讨尿转铁蛋白和血清胱抑素 C 在妊娠高血压综合征并发肾损害早期诊断的临床意义。方法在XC8001全自动生化分析仪上检测62例妊娠高血压综合征患者（试验组）的尿转铁蛋白、血清胱抑素 C、尿素和肌酐水平，并与56例健康体检者（正常组）的检测结果进行比较统计学分析。结果试验组尿转铁蛋白和胱抑素 C 水平高于正常组（P ＜0．01），尿素和肌酐高于正常组（P ＜0．05）；中度和重度妊娠高血压综合征组检测尿转铁蛋白和胱抑素C 水平明显或显著高于轻度妊娠高血压综合征组（P ＜0．05或 P ＜0．01），尿转铁蛋白和胱抑素 C 水平升高与妊娠高血压综合征的病情严重程度相关。结论尿转铁蛋白和胱抑素 C 可作为诊断妊娠高血压综合征并发肾损害早期较敏感的检测指标，其水平检测能反映妊娠高血压综合征患者肾小管和肾小球早期功能性损伤程度，对妊娠高血压综合征的早期治疗、病情进展、改善预后和围产期的不良结局干预具有积极的重要临床意义。%Objective Clinical significance in early diagnosis of renal damage of pregnancy induced hypertension syn-drome (Pregnancy-induced hypertension syndrome PIH)of urinary transferrin (Transferrin TRF)and serum Cystatin C (Cystatin C Cys-c)discuss.Methods Testing of TRF,serum Cys-c,urea (UREA)and creatinine (CREA)levels 62 cases PIH patient (experimental group)on the XC8001 automatic biochemical analyzer,and 56 cases of healthy people (normal group)testing results of for statistical compared analysis.Results The experimental group TRF and Cys-c levels are higher than normal group (P <0.01),UREA and CREA higher than that in the normal group (P <0.05);moderate and severe PIH group testing of urinary TRF and Cys-c levels were significantly higher than the mild PIH group (P <0.05 or P <0.01),increased TRF and Cys-c levels and the severity of PIH related.Conclusion TRF and Cys-C can be used as PIH complicated with renal damage diagnosis of early testing is sensitive,it can reflect the level testing in patients with PIH renal tubular and glomerular early functional damage degree,early treatment of PIH,the progress of the disease,improve the prognosis and perinatal adverse outcome intervention has important clinical signifi-cance of product.