小儿常见肾脏疾病尿电导率的变化分析

摘要

Objective To detect urine conductivity changes in pediatric common kidney disease and investgate the clinical significance of the index.Methods The urine samples of 350 healthy check-up children and 986 kidney diseases patients who were in treatment during March 2011 to March 2012 in pediatric nephrology were analyzed by Sysmex au-tomatic urine elements analyzer uf-1000i.According to the clinical diagnosis,the kidney patients were divided into ne-phrotic syndrome,glomerulonephritis,remal failure,Henoch-Schonlein purpura nephritis and lupus nephritis.According to renal biopsy pathological diagnosis,the kidney patients were divided into mesangial proliferative glomerulonephritis, capillaries proliferative glomerulonephritis,Membra-nous nephropathy,IgA nephropathy,IgM nephropathy,Henoch-Schonlein purpura nephritis and lupus nephritis.Results 1.The urine conductivity in patients with nephrotic syn-drome,glomerulonephritis,remal failure,Henoch-Schonlein purpura nephritis and lupus nephritis were significant lower than that of health control (P <0.05).2.The urine conductivity in patients with mesangial proliferative glomerulone-phritis,capillaries proliferative glomerulonephritis,membranous nephropathy,IgA nephropathy,Henoch-Schonlein pur-pura nephritis and lupus nephritis were significant lower than that of health control (P <0.05).3.There was no obvi-ous difference between patients with IgM nephropathy and the health control.(P>0.05).Conclusion The urine con-ductivity may serve as an important index in evaluating the pediatric kidney function and urine concentration.%目的：检测小儿常见肾脏疾病尿电导率的变化，探讨该指标的临床意义。方法选择2011年3月至2012年3月本院小儿肾脏内科收治的首次诊断为肾脏疾病患儿986例及同期健康体检儿童350例的尿液，利用 Sysmex 公司的全自动尿液分析仪 UF-1000i 分别测定其尿电导率的变化。根据临床诊断将肾脏疾病患儿分为肾病综合征组、肾小球肾炎组、肾功能不全组、紫癜性肾炎组和狼疮性肾炎组。其中216例进行肾穿刺活检。根据肾穿刺活检病理诊断结果将患儿分为系膜增生性肾小球肾炎组、毛细血管内增生性肾小球肾炎组、膜性肾病组、IgA 肾病组、IgM 肾病组、过敏性紫癜性肾炎组和狼疮性肾炎组。结果1．肾病综合征组、肾小球肾炎组、肾功能不全组、紫癜性肾炎组、狼疮性肾炎组患儿的尿电导率明显低于健康对照组，差异具有统计学意义（P ＜0．05）。2．系膜增生性肾小球肾炎组、毛细血管内增生性肾小球肾炎组、膜性肾病组、IgA 肾病组、过敏性紫癜性肾炎组和狼疮性肾炎组患儿尿电导率明显低于健康对照组，差异具有统计学意义（P ＜0．05）。3．IgM 肾病组与健康对照组相比，尿电导率差异无统计学意义（P ＞0.05）。结论尿电导率可以作为小儿肾脏功能和尿液浓缩功能的重要指标。