老年冠心病心力衰竭患者血清高敏C反应蛋白、N末端钠尿肽前体与左心室射血分数的相关性研究

摘要

Objective To investigate the correlation of serum hs-CRP and NT-proBNP with LVEF in elderly pa-tients with coronary heart disease.Methods 76 elderly patients with coronary heart disease were included into the ob-servation group,25 cases of elderly healthy subjects included into the control group,the serum hs-CRP,NT-proBNP levels and LVEF were compared.Results The serum hs-CRP,NT-proBNP and LVEF in the observation group were significantly higher than the control group,the difference was of statistically significant (P <0.05);the serum hs-CRP, NT-proBNP rised higher with NYHA class,LVEF was dropped,there were of statistically significant between different classification in observation group (P <0.05);the serum hs-CRP,NT-proBNP with LVEF in observation group was negatively correlated (P <0.05).Conclusion In elderly patients with coronary heart disease,the serum hs-CRP,NT-proBNP increased gradually with cardiac function and is of negative correlation with LVEF.%目的：探讨老年冠心病心力衰竭患者血清高敏 C 反应蛋白（hs-CRP）、N-末端脑钠肽前体（NT-proBNP）与左心室射血分数（LVEF）的相关性。方法选择76例老年冠心病心力衰竭患者纳入观察组，老年健康体检者25例纳入对照组，比较不同研究对象间血清 hs-CRP、NT-proBNP 与 LVEF 水平。结果观察组血清 hs-CRP、NT-proBNP及 LVEF 水平均明显高于对照组，差异具有统计学意义（P ＜0．05）；观察组心功能不同分级患者血清 hs-CRP、NT-proBNP 浓度随着 NYHA 心功能分级的升高而增高，LVEF 则逐级下降，不同分级间两两比较，差异均有统计学意义（P ＜0．05）；观察组患者血清 hs-CRP、NT-proBNP 与 LVEF 均呈负相关（P ＜0．05）。结论血清 hs-CRP、NT-proB-NP 随着老年冠心病心力衰竭患者心功能分级的递增而逐渐升高，且与 LVEF 均呈负相关。