血清中SCC-Ag、CEA和CA125联合检测在宫颈癌诊断中的意义

摘要

目的 探讨血清鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)和糖类抗原-125(CA-l25)联合检测在宫颈癌早期诊断中的临床应用价值,为宫颈癌的早期诊断和治疗提供依据.方法 选取治疗前的宫颈癌患者73例纳入研究组,选取同期健康女性100例为对照组.采用电化学发光法测定血清SCC-Ag、CEA和CA125水平.结果 研究组患者血清SCC-Ag(9.21±12.32)ng/mL、CEA(7.03±10.41)ng/mL和CA125(55.11±63.28)U/mL水平均高于对照组患者[(0.81±0.75)ng/mL、(1.15±0.66)ng/mL和(20.51±7.23)U/mL],差异有统计学意义(P<0.05).三者联合检测的灵敏度(75.3%)和准确度(87.3%)明显高于单独检测[灵敏度(SCC-Ag:52.1%,CEA:27.4%,CA125:31.5%);准确度(SCC-Ag:78.6%,CEA:67.6%,CA125:69.9%)],差异有统计学意义(P<0.05),特异度差异无统计学意义(P>0.05).结论 血清肿瘤标志物SCC-Ag、CEA和CA125联合检测可有效地提高宫颈癌诊断的敏感度,对宫颈癌的诊断具有重要的临床应用价值.%Objective To investigate the value of combined defection of squamous cell carcinoma antigen(SCC-Ag), carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA-l25)in the diagnosis of cervical cancer.Methods 73 cases of cervical cancer were included in study group,100 cases of healthy women were included in the control gmup.Electrochemical luminescence immunoassay method was used to detect the levels of SCC-Ag,CEA and CA-l25. Results The levels of serum SCC-Ag(9.21±12.32)ng/mL、CEA(7.03±10.41)ng/mL和 CA125(55.11±63.28) U/mL in cervical cancer group were higher than those in the control group[(0.81±0.75)ng/mL,(1.15±0.66)ng/mL and(20.51±7.23)U/mL](P<0.05).The sensitivity(75.3%)and accuracy(87.3%)of combined detection of SCC-Ag,CEA and CA-l25 was significantly higher than that of SCC-Ag(52.1%,78.6%),CEA(27.4%,67.6%)and CA125(31.5%,69.9%)alone group(P<0.05),but the difference between the specificity of combined detection and alone detection was not significant(P>0.05).Conclusion Combined detection of SCC-Ag,CEA and CA15 in the diag-nosis of cervical cancer has a high clinical value,it has important significance for the diagnosis of cervical cancer and can be used in clinical practice.