超声靶向破坏微泡在糖尿病基因治疗中的应用

摘要

Diabetes mellitus is a metabolic disease characterized by hyperglycemia,resulting in chronic damage and dysfunction of many organs,such as the eyes,kidneys,heart,blood vessels,nerves,etc.,which increase the difficulty of treatment for diabetes.In recent years,gene therapy for diabetes mellitus has become a hot topic.Ultrasound targeted microbubble destruction (UTMD) has the advantage of safety,good repeatability and tissue targeting,and has become a potential strategy for gene delivery.The related study progresses of UTMD in gene therapy of diabetes mellitus were reviewed in this article.%糖尿病是以高血糖为特征的代谢性疾病,常伴有各种组织,特别是眼、肾、心脏、血管、神经慢性损害和功能障碍,为治疗带来困难.近年来,糖尿病的基因治疗成为热点.超声靶向破坏微泡(UTMD)安全性高、重复性好,组织靶向高,已经成为基因潜在传递方法.本文就UTMD技术及其在糖尿病基因治疗中的研究进展进行综述.