目的 探讨不同时间服用阿司匹林且分别予钙离子拮抗剂(CCB)及血管紧张素转换酶抑制剂(ACEI)降压药联合对轻度高血压患者血压的影响.方法 120例轻度高血压患者经积极改良生活方式2个月后,血压仍未达标者,在继续生活方式改良的基础上,随机分为6组,每组20例.组1:晨服氨氯地平5 mg;组2:晨服氨氯地平5 mg+晨服拜阿司匹林100 mg;组3:晨服氨氯地平5 mg+睡前服拜阿司匹林100 mg;组4:晨服贝那普利10 mg;组5:晨服贝那普利10 mg +晨服拜阿司匹林100 mg;组6:晨服贝那普利10 mg+睡前服拜阿司匹林100 mg,观察3个月.治疗前后分别进行血压监测和血生化指标的测定.结果 治疗后6组血压均明显下降(P<0.01);组3的降压幅度明显高于其他组(P<0.05或P<0.01);组6降压幅度较组1、组2、组4、组5有所增大,但差异无统计学意义(P>0.05);阿司匹林睡前服用组的降压幅度较晨服组和不服组增高(P<0.05或P<0.01),而晨服组与不服组间比较无统计学意义(P>0.05).结论 睡前服用阿司匹林比晨服有利于降低血压,与CCB合用效果更明显.%Objective To explore the effects of aspirin with calcium channel blocker (CCB) and angiotensin - converting enzyme inhibitor(ACEI) on mild primary hypertension. Methods One hundred and twenty patients (pts) with mild hypertension were divided into six groups(n=20 in each group) :Group 1(amlodipine 5 mg administered at morning) ,Group 2 (amlodipine 5 mg and aspirin 100 mg at morning) , Group 3 (amlodipine 5 mg and aspirin 100 mg at night), Group 4 (benazepril 10 mg at the morning), Group 5 (benazepril 10 mg and aspirin 100 mg at morning) ,and Group 6 (benazepril 10 mg at morning and aspirin 100 mg at night). The blood pressures and blood biochemical indexes were monitored before and after treatment. Results After the treatment,the blood pressure in six groups was decreased obviously (P＜0.01). The blood pressure was decreased significantly in group 3 compared with that in other groups (P＜0.05 or P＜0.01). The decrease of pressure in group 6 was more than that in group 1,group 2,group 4,and group 5 (P＞0.05). The decrease extent in pts who took aspirin at night was more than that who took with or without aspirin in morning (P＜0. 05 or P＜0.01). There were no differences between the groups taking aspirin in the morning and group without taking it (P＞ 0.05). Conclusion Aspirin administered before sleeping was more favorable for blood pressure decrease than it administered in the morning. The effect would be better when pts took aspirin with CCB.
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