补肾活血方对自发性高血压大鼠血清可溶性纤维蛋白单体复合物含量的影响

摘要

目的：观察补肾活血方对自发性高血压大鼠(SHR)血清可溶性纤维蛋白单体复合物(SFMC)含量的影响。方法将28只 SHR随机分为空白对照组、吲达帕胺组、淫羊藿组及补肾活血方组，分别给予蒸馏水、吲达帕胺溶液、淫羊藿溶液、补肾活血方溶液灌胃，给药8周后，采用双抗体夹心 ABC ELISA法测定各组 SHR血清 SFMC的含量。结果与空白对照组相比，吲达帕胺组、淫羊藿组、补肾活血方组大鼠血清 SFMC含量均明显降低(P<0.01)，与吲达帕胺组和淫羊藿组比较，补肾活血方组 SFMC含量降低(P<0.01)，吲达帕胺组与淫羊藿组相比差异无统计学意义(P>0.05)。结论补肾活血方、吲达帕胺及淫羊藿均能降低 SHR血清 SFMC的含量，其中补肾活血方作用最强。%Objective To explore the effect of Bushen Huoxue decoction(BHD) on the content of serum soluble fibrin monomer com-plex(SFMC) in spontaneously hypertensive rats(SHR).Methods Twenty eight SHR were randomly divided into blank control group, indapamide group,epimedium group and BHD group,which was given distil ed water,indapamide solution,epimedium solution,BHD solution.After the treatment of 8 weeks,the content of serum SFMC was determined by ABC double antibody sandwich ELISA meth-od.Results Compared with the blank control group,the contents of serum SFMC were decreased in indapamide group,epimedium group and BHD group(P<0.01).Compared with indapamide group,epimedium group,the contents of serum SFMC were decreased in BHD group(P<0.01).Conclusion BHD,indapamide and epimedium can reduce the content of serum SFMC in SHR.