老年高血压病人高尿酸血症与血清补体C4相关性分析

摘要

Objective To study zhe relationship between elderly hypertensive patients with hyperuricemia and complement 4 (C4). Methods Four hundreds and sixty four elderly hypertensive patients in the department of Cardiology of Guang Anmen Hospital at-tached to China Academy of Traditional Chinese medical science were selected in the period of November 2013 to June 2015,228 patients were males and 236 females,mean age (78.59± 7.96)years old,137 patients with hyperuricemia were diagnosed as group A,327 patients with non hyperuricemia were as group B.The difference of complement 3(C3)and C4 were compared between the two groups.Results The levels of C3,C4,total complement (CH50)were 0.894 g/L± 0.184 g/L,0.218 g/L± 0.052 g/L,47.58 g/L± 7.38 g/L in group A,0.829 g/L± 0.175 g/L,0.200 g/L± 0.059 g/L,45.08 g/L± 7.19 g/L in group B.The levels of C3,C4 and CH50in A group were higher than that in B group(P<0.05).Spearman correlation analysis showed that C3(r=0.179,P=0.002),C4(r=0.183,P=0.002), CH50(r=0.181,P=0.002)were significantly positively correlated with hyperuricemia.Multivariate linear regression anlaysis showed that serum C4 level was independently associated with hyperuricemia,and it was an independent factor of hyperuricemia.Conclusion There may be a close relationship between hyperuricemia and the activation of the complement system in elderly patients with hy-pertension,and C4 may be an independent factor of hyperuricemia.C4 may be a predictor of disease and therapeutic target in elderly patients with hypertension and hyperuricemia.%目的：分析老年高血压病人高尿酸血症与血清补体 C4之间关系。方法选择中国中医科学院广安门医院2013年11月—2015年6月心内科住院老年高血压病人464例,男228例,女236例,年龄78.59岁±7.96岁。伴有高尿酸血症病人137例,为A组；不伴有高尿酸血症病人327例,为 B组。比较两组病人补体 C3、C4及总补体CH50水平。结果两组比较,C3：A组0.894 g/L±0.184 g/L,B组0.829 g/L±0.175 g/L；C4：A组0.218 g/L±0.052 g/L,B组0.200 g/L±0.059 g/L；CH50：A组47.58 g/L±7.38 g/L,B组45.08 g/L±7.19 g/L。A 组病人 C3、C4、CH50水平高于 B 组,两组间 C3、C4、CH50水平比较差异有统计学意义(P<0.05)；Spearman相关性分析显示,C3(r=0.179,P=0.002),C4(r=0.183,P=0.002),CH50(r=0.181,P=0.002)与高尿酸血症呈显著正相关。多元线性逐步回归分析显示,血清补体 C4水平与血清尿酸水平独立相关,是高尿酸血症的独立影响因素。结论老年高血压病人高尿酸血症与补体系统活化可能存在密切联系,补体 C4可能是高尿酸血症的独立影响因素,可能是老年高血压合并高尿酸血症的疾病预测因子和治疗靶点。