健脾扶正汤对晚期原发性肝癌患者临床疗效及免疫功能的影响

摘要

目的:观察健脾扶正汤对晚期原发性肝癌患者临床疗效及免疫功能的影响.方法:将60例患者随机分成两组,均采用相同的西医药治疗,治疗组患者加用健脾扶正汤.1个月为1疗程,两个疗程评价疗效.观察患者中医证候、肝功能、免疫功能及不良反应等.结果:两组患者中医证候疗效比较,治疗组与对照组总改善率分别为83.3％和60.0％(P＜0.05)；两组治疗后肝功能(ALT、AST、TBil)指标较治疗前均有明显改善(P＜0.05),其中ALT、AST水平治疗组较对照组改善更明显(P＜0.05).免疫功能:治疗组治疗后CD3+、CD4+水平升高,CD8+下降,CD4+/CD8+比值提高,与治疗前比较差异有统计学意义(P＜0.05)；对照组治疗前后比较差异无统计学意义(P＞0.05)；两组治疗后比较,CD3+、CD4+及CD4 +/CD8+水平差异有统计学意义(P＜0.05).不良反应治疗组明显低于对照组(P＜0.05).结论:健脾扶正汤治疗晚期原发性肝癌,能改善患者中医临床证候,提高机体免疫功能及生活质量,延长生存期.%Objective:To observe the influence on the symptom and immune function of advanced primary liver cancer patients treated with Jianpi Fuzheng decoction . Methods:A total of 60 patients were averagely randomized into treatment group and control group , which were all given the same western medical treatment. The treatment group was additionally given Jianpi Fuzheng decoction. A month for a period of treatment , to evaluate the short - term efficacy after two months . Traditional Chinese medicine symptoms , adverse reaction and immune function were observed and compared between the two groups . Results:There was significant difference in the total response rates between the two groups (83. 3% , 60. 0% , P < 0. 05) . The two group had a comparison after treatment on function of liver (ALT, AST, TBil) , which all improved (P<0. 05) , especially in the aspect of ALT and AST , the treatment group had much more significantly improved ( P < 0.05 ) . The ratio of T - lymphocyte subsets such as CD3+ , CD4+ , CD4+/CD8+ were all increased after treatment (P <0. 05) , while CD8+ decreased (P < 0. 05) ; comparison between two group showed the difference was statistically significant ( P < 0. 05 ) .In contrast , control group after treatment before treatment and comparison , the difference was not statistically significant (P > 0. 05 ) . Comparison of toxic and side effects of the two group showed the effects in the treatment group was significantly lower than the control group (P < 0. 05) . Conclusion:Jianpi Fuzheng decoction can relive clinical symptoms, improve immune function , improve quality of life and prolong survival time of patients with advanced primary liver cancer.