温阳解毒化瘀方对 HBV 相关肝衰竭患者肠道菌群的影响

摘要

Objective: To observe the effect of Wenyang Jiedu Huayu prescription on intestinal bacteria and endotoxemia in patients with HBV related liver failure.Methods: Sixty patients with HBV related liver failure were randomly divided into two groups.The treatment group ( western medical treatment +Wenyang Jiedu Huayu prescription ) enrolled 30 cases and the control group (western medical treatment) enrolled 30 cases.For 4 weeks, fecal flora and endotoxin were measured before and after treatment.Results: The efficiency of the treatment group ( 92.8%) was better than that in the control group ( 71.4%); The count of bifidobacterium significantly increased after treatment ( P<0.01); the count of enterobacteria and the level of endotox-in significantly decreased after treatment (P<0.05); Furthermore, the count of bifidobacterium significantly increased (P<0.05) and the level of endotoxin were lower (P<0.05) in the treatment group than that in the control group.Conclusion: We-nyang Jiedu Huayu prescription can treat liver failure effectively by ameliorating imbalances of intestinal bacteria and reducing the level of endotoxin.%目的：观察温阳解毒化瘀方对HBV相关肝衰竭患者肠道菌群、血浆内毒素的影响。方法：将60例中医辨证为“脾虚瘀黄”的HBV相关慢加亚急性肝衰竭患者随机分为两组，治疗组（西医治疗＋温阳解毒化瘀方）30例，对照组（西医治疗）30例，疗程共4周。测定两组患者治疗前后肠道菌群的计数、血浆内毒素水平。结果：治疗组的有效率（92.8％）优于对照组（71.4％）；治疗组患者治疗后较治疗前双歧杆菌的菌落数增加（P＜0.01），肠杆菌数量下降（P＜0.05），血浆内毒素下降（P＜0.05）；治疗组患者治疗后比对照组患者双歧杆菌数量明显增加（P＜0.05），血浆内毒素明显下降（P＜0.05）。结论：温阳解毒化瘀方治疗HBV相关肝衰竭可改善患者肠道菌群，降低血浆内毒素的水平，从而提高临床疗效。