瞬时弹性成像联合声触诊组织量化技术诊断慢性HBV携带者肝纤维化与病理的对照性研究

摘要

目的:探讨瞬时弹性成像联合声触诊组织量化技术对慢性HBV携带者肝纤维化的诊断及与病理结果的相关性.方法:选择120例慢性HBV携带者,分别采用瞬时弹性成像和声触诊组织量化技术对受试者进行检测,并与病理检测结果进行对比分析.结果:采用声触诊组织量化技术检测结果显示,慢性HBV携带者肝剪切波速随病理纤维化分期的增加而逐步增高;采用瞬时弹性成像技术检测结果示随着肝纤维化程度的加重,肝脏组织硬度值逐渐升高.由此推断,肝剪切波速度和肝脏组织硬度值越大,肝纤维化程度往往越重.两者联合应用,其敏感度、特异度、准确度均较单一检测技术高,表明两者联合应用对于肝纤维化具有更高的诊断价值.结论:瞬时弹性成像和声触诊组织量化技术可无创性地反映肝组织的弹性硬度,两者联合应用能够提高诊断的特异性、敏感性、准确性,为临床诊断和治疗肝纤维化提供更有价值的信息.%Objective:To investigate the relationship between technical diagnosis of transient elastography and virtual touch tissue quantification and liver fibrosis in pathologic of chronic hepatitis B.Methods:One hundred and twenty cases of chronic hepatitis B were selected.Transient elastography and virtual touch tissue quantification were used to detect liver fibrosis,which were compared with pathological results.Results:Liver shear wave velocity of patients with chronic hepatitis B increased with the increase of the pathologic fibrosis stage through virtual touch tissue quantification.While by using transient elastography,the stiffness of liver tissue increased gradually with the increase of the degree of hepatic fibrosis.The sensitivity,specificity and accuracy of the two combination were satisfied,which indicated that combining Fibroscan with virtual touch tissue quantification had higher diagnostic value for liver fibrosis.Conclusion:Transient elastography and virtual touch tissue quantification could noninvasively reflect the elastic stiffness of liver tissue.The combination of the two could improve the specificity,sensitivity and accuracy of diagnosis,providing more valuable information for clinical diagnosis and treatment of liver fibrosis.