杭州市十年来痢疾杆菌耐药性的变迁

摘要

1241 Strains of Shigella obtained from 1975 to 1985 in ttangzhou were found resistantv to ll types of antimiorobial in suscep%ibiLi%y test.The rates of drug-resistance to Co-TMP,sulfonamides,chloramphenicol,gentamycin.neomycin,;streptomycin,erythromyoin, furazolidone,nitrofurantoon and tetracycline showed an ineressing tendency.There Was significant difference of the rates of drug-resistance between the epidemic strains of city proper and those isolated from suburban districts. The number of multi-resistant strains Was markedly higher than that of mono-or bi-resistanl strains of Shigella sonnei and S.flexneri.The cause of change of drug sensitivity was preliminarily analysed and the mechanism of drug-resistance is discussed.%1975～1985年杭州市1241株痢疾杆菌对11种抗菌药物的敏感性试验,结果:庆大、卡那、链、红霉素、痢特灵、呋喃妥因、磺胺+TMP耐药率显示上升趋势.市区与郊(县)区分离的菌株间,其耐药率有显著性差异.1975,1979和1985年的三年中,多剂耐药菌株显著高于单剂或双剂耐药菌株.宋内氏菌与福氏菌多剂耐药菌株有所变动,本文初步分析了其变动的原因.并讨论了耐药机理.