粉尘螨滴剂通过改善机体免疫功能治疗过敏性鼻炎

摘要

目的：分析粉尘螨滴剂脱敏治疗过敏性鼻炎并腺样体肥大患儿的免疫调节功能和临床疗效。方法：选取我科2012年1月至2014年6月过敏性鼻炎并腺样体肥大患儿共80例，随机分为实验组和对照组。对照组予以依巴斯汀及左卡巴斯汀治疗，实验组在对照组的基础上，加用舌下含服粉尘螨滴剂。对比两组患者治疗前及治疗2年后的血清IL-2、IL-6水平、尘螨特异性IgE（sIgE）、尘螨总IgE（T-IgE）、尘螨特异性IgG4（sIgG4）、血液嗜酸性粒细胞（EOS）、诱导痰EOS水平。对比两组患者治疗前及治疗2年后的哮喘症状评分和鼻部症状评分。结果：两组患者治疗后的IL-2水平均显著高于治疗前，IL-6水平显著低于治疗前，P＜0.05；实验组治疗后的IL-2水平显著高于对照组，IL-6水平显著低于对照组，P＜0.05。两组患者治疗后的sIgE、T-IgE、血液EOS及诱导痰EOS均显著低于治疗前，sIgG4显著高于治疗前，P＜0.05；实验组治疗后的sIgE、T－IgE、血液EOS及诱导痰EOS均显著低于对照组，sIgG4显著高于对照组，P＜0.05。两组患者治疗后的哮喘症状评分和鼻部症状评分均显著低于治疗前，P＜0.05；实验组治疗后的哮喘症状评分和鼻部症状评分均显著低于对照组，P＜0.05。结论：在常规治疗的基础上加用粉尘螨滴剂治疗过敏性鼻炎并腺样体肥大患儿，可以有效调节患儿的免疫功能，具有良好的临床疗效。%Objective:To analyze the immune function regulation and clinical effect of dust mite drops desensitization treatment on children with allergic rhinitis.Methods:80 patients with allergic rhinitis and adenoid hypertrophy treated in our department from January 2012 to June 2014 were selected and randomly divided into experimental group and control group.Control group was treated with ebastine and levocabastine treatment, the experimental group was treated with sublingual containing Dermatophagoides Farinae Drops on the basis of control group.The level of IL-2,IL-6,house dust mite specific IgE (sIgE),dust mite IgE (T-IgE),house dust mite specific IgG4 ( sIgE in) ,blood addicted eosinophile cells ( EOS) ,and induced sputum EOS level were compared between the two groups before treatment and after 2 years treatment.Results:The level of IL-2 in the two groups was significantly higher than that before treatment,the level of IL-6 was significantly lower than that before treatment ( P<0.05 ) .After treatment, the level of IL-2 in the experimental group was significantly higher than that in the control group, the level of IL-6 was significantly lower than that in the control group( P<0.05 ).After treatment, the level of sIgE, T-IgE, blood EOS and induced sputum EOS in the two groups were significantly lower than before treatment,the level of sIgG4 were significantly higher than those before treatment (P<0.05).After the treatment,the level of sIgE, T-IgE, blood EOS and induced sputum EOS in experimental group were significantly lower than control group,and the level of sIgG4 was significantly higher than that in control group ( P<0.05).After treatment,the asthma symptom scores and nasal symptom scores of the two groups were significantly lower than before treatment (P<0.05),and those index of experimental group after treatment were significantly lower than control group ( P<0.05 ).Conclusion: Combine the basis of conventional therapy plus with Dermatophagoides Farinae Drops in the treatment of allergic rhinitis and adenoid hypertrophy children can effectively regulate the immune function of the patients,has good clinical efficacy.