知柏地黄丸与大补阴丸联合治疗中枢性性早熟患儿的临床效果分析

摘要

Objectives:To evaluate the clinical effectiveness of zhibaidihuang pill and dabuyin pill combi-nation treatment of children with central precocious puberty.Methods:1 72 patients with central precocious puber-ty,from January 201 2 to December 201 3,were selected in this study.Based on the random number table,they were randomly divided into two groups:observation group (86 patients)receiving zhibaidihuang pill and dabuyin pill combination treatment and control group (86 patients)receiving leuprolide acetate and triptorelin conventional therapy.The clinical effectiveness was observed and compared statistically.Results:In the observation group, there were 58 cases (67. 44%)with excellent results,1 2 cases (1 3. 95%)with effective results and 6 cases (6. 97%)with invalid results.In control group,there were 37 cases (43. 02%)with excellent results,20 cases (23. 25%)with valid results and 29 cases (33. 72%)with invalid results.These differences as well as the stature and the mean value of No.1 Insulin -like growth factor were statistically significant,P <0. 05 .Conclusion:Zhibaidihuang pill and dabuyin pill combination treatment have perfect clinical effectiveness in the treatment of chil-dren with central precocious puberty.%目的：研究知柏地黄丸联合大补阴丸治疗中枢性性早熟的临床效果。方法：将我院于2011年1月至2013年12月间收治的172例中枢性性早熟患儿作为研究对象，利用随机数字表法分为观察组（86例）与对照组（86例），前者给予知柏地黄丸和大补阴丸进行联合治疗，后者给予醋酸亮丙瑞林和曲普瑞林进行常规治疗，统计检测数据，评价不同治疗方法对于中枢性性早熟患儿的临床效果。结果：采用知柏地黄丸和大补阴丸进行联合治疗的86例观察组患者中，显效的有58例，占比67．44％，有效的有12 例，占比13．95％，无效的有6例，占比6．97％，总有效率为93．03％；采用醋酸亮丙瑞林和曲普瑞林进行常规治疗的86例对照组患者中，显效的有37例，占比43．02％，有效的有20例，占比23．25％，无效的有29例，占比33．72％，总有效率为66．28％；两组患者的身高和类胰岛素一号增长因子均值也存在显著差异，P＜0．05。结论：知柏地黄丸联合大补阴丸治疗中枢性性早熟能显著抑制患者心激素异常分泌，延长发育时间，减小性早熟对患者身高的影响，值得推广借鉴。