MIF、COX-2在子宫内膜异位症中的表达及相关性研究

摘要

目的:探讨MIF、COX-2与子宫内膜异位症(endometriosis,EM)的相关性研究.方法:采用免疫组织化学的方法测定EM患者49例异位内膜、40例在位的内膜及对照组正常内膜40例中MIF、COX-2的表达,并进行相关性分析.结果:(1)MIF、COX-2在EM在位内膜、异位内膜的表达率明显高于正常对照组,比较有统计学意义(P＜0.01).(2)异位和在位的内膜组中,MIF、COX-2表达在Ⅲ～Ⅳ期均高于Ⅰ～Ⅱ期,比较有统计学的意义(P＜0.05).(3)异位和在位的内膜组中,MIF表达与COX-2的表达呈正相关性(P＜0.05).结论:MIF可能通过增加COX-2表达而促进EM的发生、发展.%Objectives:To study the expression of MIF and COX-2 in endometriosis (EM) and the correlation between MIF,COX-2 and EM.Methods:MIF and COX-2 expression was detected by immunohistochemistry methods in 40 cases of eutopic endometrium and 49 eases of ectopic endometrium and 40 cases of normal endometium.The results were analyzed statistically.Results:(1) The positive expression rate MIF and COX-2 in eutopic and ectopic endometrium were much higher than those in control group (P ＜0.01).(2) In the stage Ⅲ/Ⅳ,the expression of MIF and COX-2 in eutopic and ectopic endometrium were much higher than these in stage Ⅰ/Ⅱ (P ＜ 0.05).(3) The expression of MIF was shown to be significantly correlated to COX-2 (P ＜ 0.01).Conclusion:The expression of MIF is significantly correlated to the expression of COX-2 in ectopic and eutopic endometriosis,which may play a crucial role in the pathogenesis on endometriosis.