Objective To explore epidemiological distribution and risk factors of pregnant women syphilis and congenital syphilis, and to provide basis for preventing and treating pregnant women syphilis.Methods With Case-Control study method, we respectively analyzed the risk factors of pregnant syphilis and congenital syphilis.Results The positive rate of pregnant women syphilis was 0.55%, and the incidence rate of congenital syphilis was 18/100, 000.The risk factors of pregnant women syphilis included culture level below junior high school (OR=2.499), age group from 20 to 30 (OR=3.452), flowing or tempo-rary resident population (OR=4.397), entertainment service or unemployed personnel (OR=6.910), history of venereal dis-ease (OR=3.010), history of adverse pregnancy outcome (OR=8.415) and number of sex partners in recent 5 years (OR=11.989).The influencing factors of congenital syphilis were gestational weeks of diagnosis (OR=1.296), TRUST titer of diag-nosis (OR=2.096), TRUST titer at the end of pregnancy (OR=3.028) and treatment during gestational period (OR=0.121). Conclusion The rates of pregnant women syphilis and congenital syphilis were still a little higher.We should prevent pregnant woman syphilis according to these risk factors, and we should emphasize early diagnosis, early intervention and early treatment for congenital syphilis.%目的：探讨孕产妇梅毒的流行病学分布及孕产妇梅毒、先天梅毒发生的危险因素，为防治孕产妇梅毒提供依据。方法采用病例对照的研究方法，分别分析孕产妇梅毒、先天梅毒发生的危险因素。结果孕产妇梅毒阳性率为0．55％，先天梅毒发生率为18/10万；影响孕产妇梅毒的危险因素包括初中以下文化程度（OR＝2．499）、20～30岁年龄组（OR＝3．452）、流动或暂住人口（OR＝4．397）、娱乐服务业或无业（OR＝6．910）、性病史（OR＝3．010）、既往不良妊娠结局史（OR＝8．415）、近5年性伴数（OR＝11．989）；影响先天梅毒的因素包括确诊孕周（OR＝1．296）、确诊时TRUST滴度（OR＝2．096）、妊娠结束时TRUST滴度（OR＝3．028）、妊娠期治疗（OR＝0．121）。结论孕产妇梅毒和先天梅毒的感染率仍然较高，预防孕产妇梅毒应针对其危险因素采取有效措施，而先天梅毒应重视早诊断、早干预及早治疗。
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