早期HP联合CVVH治疗急性百草枯中毒的效果评价

摘要

Objective To explore the effect of early HP combined with CVVH treating acute paraquat poisoning ( PQ) . Methods One hundred and eighty-three patients with PQ were divided into control group (75 cases), HP group (65 cases) and HP+CVVH group (43 cases) according to treatment methods. The survival rates of 3rd, 7th and 60th days were compared among the three groups, and their prognosis effects were analyzed. Results The survival rates of 3rd, 7th, 60th days in the HP+CVVH group were respectively 86. 0%, 65. 1% and 46. 5%, much higher than those in the control group (56. 0%, 41. 3%, 21. 3%, all P<0. 05). The survival rates of 3rd, 7th, 60th days in the HP group were respectively 75. 4%, 56. 9% and 43. 1%, much higher than those in the control group (56. 0%, 41. 3%, 21. 3%, all P<0. 05). The median survival days of HP+CVVH group and HP group were respectively 40 days and 15 days, both much higher than those the control group (3 days, P<0. 01). Con-clusion Blood purification techniques ( HP, CVVH) could obviously raise median survival days and survival rate of prognosis. Finding out the timing of blood purification and treatment time of acute parquat poisoning could provide basis for clinical populari-zation.%目的：探讨早期HP联合CVVH治疗急性百草枯( PQ)中毒的临床效果。方法将确诊的183例PQ中毒患者依据治疗方法，分为对照组(75例)、单纯HP组(65例)和HP+CVVH组(43例)；比较3组的3天、7天、60天生存率，分析预后效果。结果 HP+CVVH组3天、7天、60天生存率分别为86.0%、65.1%、46.5%，均明显高于对照组的56.0%、41.3%、21.3%(均有P<0.05)；HP组的3天、7天、60天生存率分别为75.4%、56.9%、43.1%，均明显高于对照组的56.0%、41.3%、21.3%(均有P<0.05)。 HP+CVVH组、HP组的中位数生存时间分别为40天、15天，均明显高于对照组的3天(P<0.01)。结论血液净化技术(HP、HP+CVVH)可明显提高PQ中毒患者的中位数生存时间和预后生存率。摸清急性百草枯中毒的血液净化时机和治疗时间，能够为临床推广提供依据。