乙醛脱氢酶2通过自噬修复器官缺血再灌注损伤的研究进展

摘要

随着我国公民器官捐献的快速发展,心脏死亡器官捐献(DCD)供体器官已获广泛采用.为此,DCD供体的质量,包括如何保存、维护器官的质量亦成为目前面临的重大问题.缺血再灌注损伤对器官质量有着很大的影响.研究表明乙醛脱氢酶2 (ALDH2)可在包括缺血再灌注损伤在内的众多应激条件下为各种器官提供保护,自噬的激活与抑制也可在不同应激条件的器官保护中发挥作用,而ALDH2则可通过调节自噬减少器官缺血再灌注损伤.本文旨在概述这种修复机制的研究进展.%With the rapid development of organ transplantation in China,the donation after cardiac death (DCD) donor organs are widely used.However,the quality of these organs is relatively poor,so the way to preserve and maintain organ still remains a severe problem.Among them,ischemic reperfusion injury (IRI) impairs the organs severely.Acetaldehyde dehydrogenase 2 (ALDH2) protects organs from stress conditions,including ischemia-reperfusion injury,and the activation and autophagy inhibition also protects the organs from stress conditions as well.Recent studies showed that ALDH2 can regulate autophagy to inhibit the organ injury during ischemia-reperfusion.Our study aims to discuss the new findings in this mechanism.