常温机械灌注在心脏死亡捐献供肝保存中的作用

摘要

心脏死亡捐献器官(DCD)是扩大供肝池的重要来源.相较于脑死亡捐献器官(DBD),DCD供肝更容易出现长时间缺血缺氧,从而导致严重损伤,这使DCD器官移植受到很大的限制.常温机械灌注可通过持续携氧灌流最大程度地模拟离体肝脏的在体生理状态,维持细胞生理代谢和肝脏活性,甚至修复肝脏损伤.本文就DCD肝脏常温机械灌注在临床和实验中的研究进展做一综述.%Donation after cardiac death (DCD) may be an important way to expand the liver organ donor pool.Compared with donation after brain death (DBD), the clinical utilization of DCD organ is limited by ischemia and hypoxia.Normothermic machine perfusion (NMP) mimics the physiologic state of the liver through continuous perfusion after procurement, creating an optimal environment for the organ to stay viable, metabolize and even reverse sustained damage.This review summarizes the recent experimental and clinical research progress on NMP of DCD liver.