胃肝样腺癌:一种易误诊为原发性肝癌的特殊类型的胃腺癌

摘要

Gastric hepatoid adenocarcinoma (GHA) is a rare but important sub-type of gastric adenocarcinoma characterized by high serum α-fetoprotein,early lymphatic and hepatic metastasis,and poor prognosis.Clinically,the presentation could be atypical,liver neoplasm could be the initial finding.With similar clinicopathological presentation as hepatocellular carcinoma (HCC),prompt and correct diagnosis can be a challenge,especially in endemic areas with a high incidence of HCC.Once diagnosed,surgical removal remains the treatment of choice.This review focus on advancement on the biological,histological and immunohistological features,and the clinicopathological presentation of GHA.%胃肝样腺癌(GHA)是一种罕见但重要的胃腺癌亚型.其特征是血清AFP升高,早期发生淋巴结、肝脏转移,预后差.由于临床表现不典型,患者常常以肝占位为首发症状,加之临床特征、病理的相似性,极易误诊为肝细胞癌.在原发性肝癌高发地区准确术前诊断GHA尤为困难.研究GHA的生物学特性以及临床和组织病理学特点,对疾病的早期诊治具有重要意义.本文对GHA的诊疗现状与进展做一综述.