胃癌患者血清中胰岛素、CEA、铁蛋白和转化生长因子-β1水平诊断的临床研究

摘要

目的 为了探讨胃癌患者血清中胰岛素(Ins)、癌胚抗原(CEA)、铁蛋白和转化生长因子-β1(TGF-β1)水平诊断的临床意义.方法 化学发光免疫分析(CLIA)测定了106例胃癌患者血清中的Ins、CEA和铁蛋白的水平,酶联免疫分析(ELISA)测定了TGF-β1水平,并与50名正常对照组进行了比较性分析.结果 106例胃癌血清Ins、CEA、铁蛋白和TGF-β1水平较之50名正常对照组明显增高(P均＜0.01),31例胃癌Ⅰ～Ⅱ期、32例Ⅲ期和43例Ⅳ期的血清CEA和TGF-β1 水平较之正常对照组增高最为明显(P均＜0.01),其次为血清铁蛋白的水平,最后为血清Ins水平;但血清Ins、CEA、铁蛋白和TGF-β1水平均随胃癌的严重程度而增加.结论 在胃癌的诊断中,以血清CEA和TGF-β1水平测定为最佳,其次为Ins 和铁蛋白水平,故四种肿瘤标志物的联合测定具有特殊的临床价值.%Objective To explore the clinical study on diagnosis of gastric carcinoma by determining serum insulin(Ins),CEA,ferritin(SF) and transforming growth factor-β1(TGF-β1) levels. Methods The levels of Ins,CEA,and SF[with chemiluminescent immunoassay assay(CLIA)]and TGF-β1[with enzyme-linked immunosorbent assay(ELISA)] were determined in 106 gastric carcinoma and 50 normal controls. Results The serum Ins,CEA, SF and TGF-β1 levels in 106 patients with gastric carcinoma were significantly higher than those in 50 normal controls.The serum CEA and TGF-β1 levels in 106 patients with gastric carcinoma (including 31 case stage I-II gastric carcinoma,32 cases stage III gastric carcinoma,43 cases stage IV gastric carcinoma) were significantly high than those in 50 normal controls.The serum Ins,CEA,SF and TGF-β1 levels in 106 patients with gastric carcinoma were increased with severity of gastric carcinoma. Conclusion In diagnosis of gastric carcinoma,the best chooser of four tumor markers were serum CEA and TGF-β1 levels. There were special clinical value in combined determination of Ins,CEA,SF and TGF-β1.