基于患者个体水平数据成本效果分析的主要问题和方法

摘要

通过对国内外研究者的观点和解决方法进行整理总结,对基于患者水平数据的成本—效果分析的一般原则进行系统论述,并对分析中需要注意的问题进行探讨,包括分析数据集的选择,缺失/删失数据的处理,是否进行贴现的考虑,不确定性分析的使用,统计分析计划的制定,中间访视点的数据分析,协议驱动成本的处理等内容.%By summarizing considerations and suggested solutions of domestic and foreign researchers,the gen-eral analysis principles of cost-effectiveness analysis based on patient level data are systematically discussed,as well as the problems that need to be paid attention in the analysis,including the analysis of data set,solution of missing/censored data,consideration of whether discount should be conducted,the use of uncertainty analysis, the prepara-tion of statistical analysis plan,the analysis of intermediate follow-up point data,handling the protocol-driven costs, etc. The paper has provided reference and discussion points for the pharmaceutical economists or readers who may have interest.