维生素B12联合绞股蓝煎剂对复发性口腔溃疡患者T淋巴细胞亚群、溃疡面积及疼痛评分影响研究

摘要

目的 探讨维生素B12联合绞股蓝煎剂对复发性口腔溃疡患者T淋巴细胞亚群、溃疡面积及疼痛评分的影响.方法 选取本院口腔门诊已确诊为复发性口腔溃疡的患者81例,采用随机数表法将患者分为试验组41例和对照组40例.对照组予贝复济局部喷于溃疡面,试验组在对照组基础上加用维生素B12片和绞股蓝煎剂联合治疗,治疗2周.观察两组患者T淋巴细胞亚群、溃疡面积、疼痛评分及临床疗效.结果 与对照组相比,试验组患者溃疡面积、疼痛评分、溃疡愈合时间均低于对照组(P<0.05);试验组CD3+、CD4+、CD4+/CD8+水平高于对照组,血清CD8+低于对照组(P<0.05);试验组总有效率高于对照组(P<0.05);治疗后6个月试验组复发率明显低于对照组,差异均有统计学意义(P<0.05).结论 维生素B12联合绞股蓝煎剂能有效调节复发性口腔溃疡患者免疫功能,改善临床症状,降低复发率,对临床治疗复发性口腔溃疡具有重要意义.%Objective To explore the effect of vitamin B12combined with gynostemma decoction on T lymphocyte subsets, ulcer area and pain score in recurrent oral ulcer patients. Methods Eighty-one patients with recurrent oral ulcer were randomly divided into 2 groups.The control group was treated with local injection of basic fibroblast growth factor on the ulcer surface,and the experiment group was treated on the base of the control group with vitamin B12and gynostemma decoction.T lymphocyte subsets,ulcer area and pain score were compared after treatment. Results Compared with the control group,the ulcer area,pain score,and ulcer healing time of the experiment group were lower(P<0.05);CD3+,CD4+and CD4+/CD8+of the experiment group were higher;and CD8+was lower(P<0.05).The total efficacy rate of the experimental group was higher(P<0.05).The recurrence rate of the experimental group was significantly lower than that of the control group at 6 months after treatment(P<0.05).Conclusion Vitamin B12combined with gynostemma decoction can effectively regulate the recurrence of oral ulcer in patients with improved immune function,improved clinical symptoms,and reduced recurrence rates.It has vital significance for the clinical treatment of recurrent oral ulcers.