高龄老年高血压人群血尿酸浓度与脑梗死的相关性研究

摘要

Objective To evaluate the relation between serum UA and cerebral infarction.Methods Five hundred and seventy-two very elderly hospitalized patients with hypertension in the Department of Geriatrics were divided into two groups.Three hundred and eighty-seven patients who werent diagnosed with cerebral infarction formed group Ⅰ while one hundred and eighty-five patients with cerebral inffaretion belonged to group Ⅱ.Blood biochemical patterns and clinical medical history were compared between two groups.Results The level of serum UA in group Ⅰ is(312.49±55.31 )/μmol/L,the Cr is(86.48±18.38)μ mol/L,and the HDL-C is(1.29±0.37)mmol/L,while the group Ⅱ is(397.76±63.64)μmol/L, (100.52±19.99)μmol/L and(1.11±0.33)mmol/L.Apparently,the level of UA ,Cr and HDL-C are significantly different between the two groups.Logistic regression analysis showed that UA (OR=1.727,95％CI 1.258～3.903 )was positively correlated with prevalence of cerebrat infarction.Conclusions Serum UA is the risk factors of cerebral infarction.%目的 探讨高龄老年高血压患者血尿酸(UA)水平与脑梗死的关系.方法 选取2009年在我院老年科住院的年龄≥80岁的高血压和脑梗死患者572例,根据所患疾病分为高血压组(Ⅰ组387例)和高血压合并脑梗死组(Ⅱ组185例),测定UA、血清肌酐(Cr)、高密度脂蛋白胆固醇(HDL-C)、血糖等生化指标,分析UA水平与高血压合并脑梗死的相关性.结果 Ⅰ组UA为(312.49±55.31)μmol/L、Cr为(86.48±18.38)μmol/L、HDL-C为(1.29±0.37)mmol/L;Ⅱ组UA为(397.76±63.64)μmol/L、Cr为(100.52±19.99)μmol/L、HDL-C为(1.11±0.33)mmol/L.两组比较分别为P=0.001、P=-0.001、P=0.024.Logistic回归分析显示,脑梗死患病率与UA(OR 1.727,95%CI 1.258～3.903)和HDL-C(OR 0.794,95%CI 0.663～0.975)明显相关.结论 UA增高是高血压合并脑梗死的一个重要危险因素.