血管紧张素转化酶基因多态性与中国人群消化道肿瘤易感性的 Meta 分析

摘要

Objective To study the relationship between angiotensin -converting enzyme(ACE)gene I /D polymorphisms and suscep-tibility to digestive system cancer in Chinese populations by Meta -analysis.Methods Computer literature searching was carried out in CBM and PubMed database to collect the articles of the case -control studies on association between ACE polymorphism and susceptibility to diges -tive system cancer.Odds ratio was employed to evaluate the susceptibility to digestive system cancer and ACE status .Heterogeneity was checked by chi-square test.Publication bias was assessed by a funnel plot and Egger 's test.Results Six papers were selected.Meta-analysis found that OR(95%CI)of D allele compared with that of I allele was 1.32(0.46 ~3.79)(P>0.05).OR(95%CI)of DD genotype compared with that of DI /II genotype was 0.89(0.39 ~2.01)(P>0.05).OR(95%CI)of DD/DI genotype compared with that of II genotype was 1.08 (0.89 ~1.31)(P>0.05).OR(95%CI)of DD genotype compared with that of II genotype was 0.86(0.43 ~1.75)(P>0.05).OR(95%CI)of DI genotype compared with that of II genotype was 1.02(0.74 ~1.40)(P>0.05).Conclusions Angiotensin-converting enzyme pol-ymorphisms may not be significantly associated with digestive system cancer in Chinese populations .%目的：通过 Meta 分析评估血管紧张素转化酶（ACE）基因 I ／D 多态性与中国人群消化道肿瘤发病的相关性。方法通过计算机文献检索中国生物医学文献数据库（CBM）和 PubMed 数据库，并结合文献追溯的方法，收集所有关于 ACE 基因多态性与消化道肿瘤易感性的病例对照研究或队列研究。以消化道肿瘤组与对照组人群基因型分布的 OR 值为效应指标，各资料间进行一致性检验，以确定采用固定或随机效应模型进行合并分析。发表偏倚用漏斗图和 Egger 线性回归检验来评估。结果纳入在国内外发表的相关文献6篇，Meta 分析结果表明：D 等位基因相对于 I等位基因合并 OR 值（95％ CI）为1.32（0.46～3.79）（ P＞0.05），DD 基因型相对于 DI ／II 基因型合并 OR 值（95％CI）为0.89（0.39～2.01）（ P＞0.05），DD ／DI 基因型相对于Ⅱ基因型合并 OR 值（95％CI）为1.08（0.89～1.31）（P＞0.05），DD 基因型相对于Ⅱ基因型合并 OR 值（95％CI）为0.86（0.43～1.75）（P＞0.05），DI 基因型相对于 II 基因型合并 OR 值（95％CI）为1.02（0.74～1.40）（ P＞0.05），差异均无统计学意义。结论中国人群ACE 基因 I ／D 多态性与中国人群消化道肿瘤易感性无明显关联。