维吾尔族阿尔茨海默病患者认知功能障碍与颈动脉粥样硬化的关系

摘要

目的 探讨维吾尔族阿尔茨海默病(AD)患者认知功能障碍与颈动脉粥样硬化的相关性.方法 样本来源于2014年1月至2015年6月乌鲁木齐第四人民医院维吾尔族AD患者180例,以同年龄段健康者175例作为对照组.采用简易智力状态检查(MMSE)和AD评定量表-认知部分(ADAS-Cog)评定认知功能,采用颈部血管超声检查颈动脉粥样硬化情况.结果 AD组MMSE分值、ADAS-Cog总分及各因子分、颈部血管粥样硬化斑块发生率及双侧CCA、右侧ICA的IMT值与对照组之间有差异(P<0.05或<0.01),且双侧CCA、右侧ICA的IMT值与MMSE、ADAS-Cog评分有显著相关性(β=-0.871,0.642,0.572,-0.771,0.659,-0.512,P<0.05或P<0.01).结论 维吾尔族AD 患者存在颈部粥样硬化改变,且双侧CCA、右侧ICA的IMT与认知功能损害有一定的相关性.%Objective To explore the relationship between cognitive impairment and carotid artery atherosclerosis in Uygur Alzhei-mer's disease(AD) patients.Methods Totally 180 AD patients were collected as AD group and 175 normal persons with similar age were ar-ranged as control group.The cognitive function was assessed by Mini-Mental State Examination(MMSE) and AD Assessment Scale-Cognitive portion(ADAS-Cog).The carotid artery atherosclerosis was measured by carotid artery ultrasound.Results Compared with those of control group,the scores of MMSE and ADAS-Cog,arteriosclerotic plaques,IMT in bilateral common carotid arteries(CCA) and right internal carotid artery(ICA)were significantly higher than those in AD group(P<0.05 or<0.01).Among all the related factors,IMT in bilateral CCA and right ICA were related to MMSE and ADAS-Cog remarkably(β=-0.871,0.642,0.572,-0.771,0.659,-0.512,P<0.05 or<0.01).Con-clusions Carotid artery atherosclerosis commonly occurs in Uygur AD patients,and meanwhile IMT in bilateral CCA and right ICA are close-ly associated with cognitive impairment.