Raman, Infrared, or Infrared Raman Analysis of Peripheral Blood Plasma Protein Structure and Its Relationship to Cognitive Development in Alzheimer's Disease

摘要

Raman, Infrared, or Infrared Raman Analysis of Peripheral Blood Plasma Protein Structure and its Relationship to Cognitive Development in Alzheimer's Disease The present invention relates to a Raman spectroscopy method for determining the structure of the associated protein with overall cognitive impairment in alzheimer's disease from Raman spectroscopic analysis of a human blood sample, preferably a human blood plasma sample, comprising obtaining at least one spectral value from at least one of the regions raman spectrum of 1600–1700 cm-1, 910–980 cm-1, 730–760 cm-1 and / or 390–450 cm-1, and where said spectral value gives a indication of the presence or absence of the protein structure associated with an alzheimer's disease condition. The present invention also relates to a method for the analysis of infrared spectroscopy of a blood sample by additionally obtaining at least one spectral value from at least one of the regions of the infrared spectrum between 1600 and 1700. cm-1, and / or between 1000 and 1150 cm-1 and / or between 1140 and 1190 cm-1. optionally, the Raman spectroscopy method further comprises infrared spectroscopy analysis of the same blood sample. The invention also relates to a diagnostic method for diagnosing Alzheimer's disease comprising measuring a raman spectrum and / or an infrared spectrum of a plasma sample.