目的 探讨胫骨定量超声(QUS)骨量分析系统预测老年妇女骨折危险性的临床实用性以及骨折的阈值。 方法 采用QUS技术检测63例骨折患者(骨折组)和85名社区健康老年妇女志愿者(对照组)的胫骨超声传导速度（SOS）值，并对其变化规律进行分析。 结果 骨折组的SOS值(3 712.7 m/s)明显低于对照组（3 831.4 m/s，P＜0.01），且SOS值与骨折危险性呈负相关，SOS值每下降100 m/s，骨折危险性增加约1倍。若以骨折危险性高于20%为骨折高危人群，则骨折的SOS阈值为3 850 m/s。 结论 胫骨QUS测量对诊断老年妇女骨质疏松症和预测骨折危险性有很大的临床应用潜力。%Objective To study the clinical application on the assessment of fracture risk and prediction of the fracture threshold by quantitative ultrasound(QUS) bone measurement in elderly women. Methods In a case-control study, we examined 85 healthy volunteer women and a group of 63 female patients with recent fracture. The value of SOS analysis was used to compare decreases in women with or without fracture. Results In women with fracture, the value of SOS in the tibia was significantly lower than that in healthy control subjects (3 712.7 m/s vs 3 831.4 m/s, P＜0.01). The relationship between the value of SOS and risk of fracture was analysed by logistic regression, showing that the risk of fracture was inversely related to the value of SOS. As SOS decreased by 100 m/s, the risk of fracture increased by two times. When the threshold limit value of SOS to screen the population at more than 20% risk of fracture in elderly women was 3 850 m/s. Conclusions The measurement of tibia SOS is useful in clinical application on the diagnosis of osteoporosis and the prediction of fracture in elderly women.
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