Objective To explore the association between the single nucleotide polymorphism (SNP) of 8q24(rs1016343,T,rs13252298,G and rs6983561,C)genes and prostate cancer (Pca) in Chinese population in Beijing,and to analyze the relationship between these genotypes and clinical characteristics in patients with prostate cancer.Methods Based on a case control study,289 patients with prostate cancer and 288 age-matched control subjects were recruited.The differences of allele and genotype frequencies of 8q24(rs1016343,rs13252298 and rs6983561) genes were analyzed between the two groups and the relationships between different genotypes and clinical features such as age,body mass index (BMI),Gleason score,prostate specific antigen (PSA) level and tumor stage were investigated.Results There was significant difference in the frequency distribution of CC genotype of SNP rs6983561 between case and control groups(OR=1.91,P-0.044).The frequency distribution of CC+TC genotypes of SNPrs1016343 had significant differences among the PCa patients with different ages (P =0.00).The frequency distribution of CC/AC+AA genotypes of SNP rs6983561 had significant differences among the PCa patients with different tumor stage,progressive type and BMI (P=0.046,0.034 and 0.021).The cumulative effects test of risk alleles (rs1016343 and rs6983561) showed that the risk of PCa in patients carrying 1,2,≥3 risk alleles was respectively 1.332,1.416 and 1.519 folds more than that in controls.Conclusions The risk allele C of rs6982561 may be associated with the risk of Pca,tumor stage,progressive type and BMI in people in north China,and age may be correlated with the risk of PCa in people carrying risk allele T of rs1016343.%目的 探讨8q24 region2单核苷酸多态性(SNP)基因(rs1016343,T)、(rs13252298,G)和(rs6983561,C)与前列腺癌(PCa)患病发病风险的关联,分析这些基因型与PCa患者临床特征的关系. 方法 采用病例对照研究设计,比较病例组(289例)PCa患者和对照组(288例)健康人的等位基因和基因型频率的差异,并探讨各基因变异与患者的确诊年龄、体质指数、Gleason评分、前列腺特异性抗原水平、肿瘤分期等临床特征间的关系. 结果 病例组和对照组rs6983561的CC基因型频率分布比较,差异有统计学意义(OR=1.91,P=0.044).不同年龄的PCa患者中,rs1016343的CC+TC基因型分布频率差异有统计学意义(P=0.000).不同肿瘤分期、进展期和体质指数的PCa患者rs6983561的CC/AC+ AA基因型的分布频率差异有统计学意义(P=0.046;P=0.034;P=0.021).对rs1016343和rs6983561风险基因型进行累积效应分析结果显示,当PCa患者携带0、1、2、≥3个风险基因型时,发生PCa的风险将分别为对照组的1.332、1.416和1.519倍. 结论 染色体8q24 region2 SNP(rs6982561,C)可能与中国北方人PCa患病风险和肿瘤分期、进展期和体质指数有关,8q24基因(rs1016343,T)的年龄可能与PCa的患病风险有关.
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