骨桥蛋白和脂蛋白a及载脂蛋白与动脉粥样硬化病变的关系

摘要

目的 分析血浆骨桥蛋白(OPN)、血清脂蛋白a[LP(a)]、血浆载脂蛋白B/载脂蛋白ApoB/ApoA1)的变化与动脉粥样硬化病变的关系. 方法 回顾性分析,随机选取天津市第三中心医院2014年3月到2015年11月收治的120例老年动脉粥样硬化患者为观察组,并选择同期健康体检的健康老年人120例为对照组,对两组受试者血浆OPN、LP(a)、ApoB/ApoA1进行检测,分析血浆OPN、LP(a)、ApoB/ApoA1变化同动脉粥样硬化病变间的关系. 结果 观察组患者血浆OPN(33.2±10.1)μg/L、LP(a) (357.6±66.5)mg/L、ApoB/ApoA1 0.8±0.7,均高于对照组(30.6±9.1)μg/L、LP(a) (120.5±35.7) mg/L、ApoB/ApoA10.6±0.1,差异有统计学意义(t值分别为:8.91、8.43、6.01,P值分别为0.021、0.035、0.041);随着动脉粥样硬化病变程度加重,血浆OPN、ApoB/ApoA1、LP(a)的浓度呈上升趋势,且差异有统计学意义(F值分别为8.50、7.38、6.41,P值分别为0.031、0.039、0.037). 结论 动脉粥样硬化患者血浆OPN、LP(a)、ApoB/ApoA1水平增加,且随动脉粥样硬化病变程度加重而增高.%Objective To evaluate the relationship of the plasma levels of osteopontin(OPN),lipoprotein (a) [Lp (a)] and apolipoproteinA/apolipoproteinB (ApoB/ApoA1) ratio with atherosclerosis.Methods 120 elderly patients with atherosclerosis (observation group) and another 120 healthy elderly subjects (control group) from Health Check Department in Tianjin Third Center Hospital were enrolled from Mar.2014 to Nov.2015.The levels of plasma OPN,Lp(a) and ApoB / ApoA1 ratio were measured and their relationship with atherosclerosis was analyzed.Results In observation group versus control group,the levels of plasma OPN[(33.2±10.1) μg/L vs.(30.6± 9.1) μg/L],ApoB/ApoA1 ratio[(0.8±0.7) vs.(0.6±0.1)]and Lp(a)[(357.6±66.5) mg/L vs.(120.5±35.7) mg/L] were increased with statistically significant differences (t =8.91,8.43,6.01;P=0.021,0.035,0.041).The concentrations of plasma OPN,ApoB/ApoA1 ratio and Lp (a) were increased along with aggravation of artery lesion,with statistically significant differences (F =8.50,7.38,6.41;P=0.031,0.039,0.037).Conclusions The plasma levels of OPN,Lp(a) and ApoB/ ApoA1 ratio are increased in patients with atherosclerosis and increased along with the lesion aggravation.