血小板与淋巴细胞比值对冠状动脉病变及介入治疗预后的预测价值

摘要

Objective To study the value of platelet/lymphocyte ratio(PLR)in predicting coronary artery lesions and their outcome in acute coronary syndrome(ACS)patients after PCI.Methods Three hundred and forty-four elderly ACS patients who underwent PCI and CAG in our hospital from May 2016to August 2018were divided into MACCE group(n=95)and MACCE-free group (n=249).They were further divided into high PLR group(n=247)and low PLR group(n=97) according to the ROC curve for PLR.Their clinical data were analyzed,and the prognostic threshold of PLR was determined according to the ROC curve for PLR and logistic regression analysis respectively.Results The number of smokers was significantly greater,the incidence of DM,serum LDL-C level,PLR and Gensini score were significantly higher in MACCE group than in MACCE-free group(P＜0.01).The area under the ROC curve for PLR in predicting the poor outcome in ACS patients after PCI was 0.898and 0.842respectively(95％CI:0.859-0.937,95％CI:0.794-0.891).The PLR was positively related with the Gensini score(r=0.654,P＜0.01).The incidence of MACCE was significantly higher in high PLR group than in low PLR group(78.35％ vs 7.69％,P＜0.01).High PLR was an independent risk factor for MACCE in elderly ACS patients after PCI(OR=2.527,95％CI:1.058-6.039,P=0.037).Conclusion PLR is related with MACCE in elderly ACS patients after PCI.%目的 探讨血小板与淋巴细胞比值(PLR)对老年急性冠状动脉综合征(ACS)患者冠状动脉病变及PCI预后的预测价值.方法 选择2016年5月～2018年8月我院住院治疗的老年ACS患者344例,均接受PCI及冠状动脉造影,根据PCI术后有无主要不良心脑血管事件(MACCE)分为MACCE组95例和无MACCE组249例;根据PLR判断预后界值分为高PLR组247例(PLR≥137.6)和低PLR组97例(PLR＜137.6).回顾分析患者一般临床资料等,用ROC曲线确定PLR判断预后的界值,行logistic回归分析.结果MACCE组吸烟、糖尿病、LDL-C、PLR及Gensini评分均较无MACCE组高(P＜0.01);PLR和Gensini评分预测PCI预后不良的曲线下面积为0.898(95％CI:0.859～0.937)和0.842(95％CI:0.794～0.891);PLR水平与Gensini评分呈正相关(r=0.654,P＜0.01).高PLR组总MACCE发生率明显高于低PLR组(78.35％vs 7.69％,P＜0.01),术前高PLR水平是预测老年ACS患者PCI术后发生MACCE的独立危险因素(OR=2.527,95％CI:1.058～6.039,P=0.037).结论PLR与老年ACS患者PCI术后发生MACCE有关.