Objective To analyze the effect of carotid artery stenting (CAS) on cognitive function and life quality of patients with severe internal carotid artery (ICA) stenosis (≥70% ) .Methods Thirty-two patients with severe ICA stenosis (≥70% ) but without massive cerebral stroke who underwent CAS were included in this study .Their cognitive function was assessed with mini mental state examination (MMSE) and visual retention test (VRT ),respectively ,before and 3 months after operation .Their quality of life(QOL) was monitored with WHOQOL-BREF .Results The CAS was successful for all patients , with a success rate of 100% .The incidence of ICA stenosis was significantly lower whereas the MMSE ,VRT and WHOQOL-BREF scores were significantly higher before operation and 3 months after operation(83 .4% ± 7 .6% vs 4 .3% ±1 .3% ,P<0 .01; 21 .3 ± 2 .7 vs 24 .6±2 .4 , P<0 .05 ) .The error VRT score was significantly lower 3 months after operation than before operation ( P<0 .05 ) .Asymptomatic cerebral stroke relapsed during the fol -low-up .Conclusion Severe ICA stenosis is one of the reasons for cognitive impairment in such patients .CAS can improve their cognitive function and quality of life .%目的 观察颈动脉支架成形术(CAS)对颈内动脉重度狭窄患者认知功能与生活质量的影响.方法 选择32例未发生大面积脑梗死的重度颈动脉狭窄(狭窄程度≥70%)患者行CAS,手术前及术后3个月采用简易智能状态检查量表(MMSE)及视觉保持测验(VRT)观察认知功能的变化,用WHO生存质量量表简表(WHOQOL-BREF)观察患者生活质量变化.结果 所有患者均成功行CAS,成功率100%.与术前颈动脉狭窄率比较,术后3个月狭窄率明显降低[(83.4±7.6)% vs (4.3±1.3)%,P＜0.01];与术前比较,术后3个月MMSE评分、VRT正确计分、WHOQOL-BREF评分明显升高,差异有统计学意义(P＜0.05);VRT错误计分明显降低,差异有统计学意义(P＜0.05).随访期无症状性脑卒中复发.结论 严重颈动脉狭窄可能是导致患者认知功能障碍的原因之一,CAS可以改善患者的认知功能和生活质量.
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