抗菌肽应用于不同牙周袋深度患牙的效果评估

摘要

目的:比较抗菌肽RISE-AP12(R)应用于不同深度牙周袋患牙辅助治疗后的效果.方法:将60例慢性牙周炎患者根据所用药物随机分为RISE-AP12(R)组、盐酸米诺环素组及空白对照组.各组龈下刮治后牙周袋内上药,1次/周,共4次.各组患牙刮治前及刮治后3个月复诊时牙周探诊,记录牙周袋深度、出血指数及附着丧失;根据牙周袋深度对患牙进行分组:4-6mm组、6-8mm组及大于8mm组,对比RISE-AP12(R)、米诺环素在不同牙周袋深度患牙中的临床治疗效果.结果:1.各药物组患者治疗后探诊深度、出血指数和附着丧失均较治疗前明显降低,同组治疗前后差异有统计学意义(P＜0.05);2.RISE-AP12(R)组、米诺环素组治疗前后探诊深度、出血指数和附着丧失的改善程度均优于空白对照组,差异有统计学意义(P＜0.05);3.比较牙周袋深度在4-6mm和6-8mm患牙治疗前后出血指数、牙周袋深度和附着丧失变化幅度,RISE-AP12(R)组和米诺环素组均大于空白对照组,差异有统计学意义(P＜0.05);比较牙周袋深度大干8mm患牙治疗前后出血指数、牙周袋深度和附着丧失的变化幅度,空白对照组、米诺环素组、RISE-AP12(R)组的变化幅度依次升高,且差异有统计学意义(P＜0.01).结论:应用抗菌肽和盐酸米诺环素辅助治疗不同牙周袋深度牙周炎患牙,均能达到较好疗效,具有一定的临床应用价值.%Objective:To investigate the clinical effects of antibacterial peptide on the treatment of different periodontal pockets depth in patients with periodontal disease.Methods:A total of 60 cases of chronic periodontitis (CP) patients were incorporated and randomly divided into RISE-AP12(R) group,minocycline hydrochloride (MINO) group and control group.Following mechanical treatment,corresponding medicine was applied in the impacted teeth,once a week,4 time for a course of treatment.Periodontal examination was performed at 3 months before and after scaling,and the depth of periodontal pocket,bleeding index and attachment loss were recorded Impacted teeth were further divided into three groups according to different pocket depth:4-6mm group,6-8mm group and ＞8mm group,to analyze and compare the clinical therapeutic effect of AMP and MINO on periodontal pockets of different depth.Results:1.The probing depth,bleeding index and clinical attachment loss were significantly reduced in the three groups after treatment,and the differences were statistically significant among groups before and after treatment (P＜0.01);2.Probing depth,bleeding index and clinical attachment loss in the AMP group and MINO group were all superior to those in the control group,with statistical difference (P＜0.05);3.comparison results of probing depth,bleeding index and clinical attachment loss among groups with the depth of periodontal pocket at 4-6mm and 6-8mm suggested that there were statistical differences of indexes in the AMP group and MINO group when compared with those in the control group (P＜ 0.05);Comparison:of bleeding index,probing depth and attachment loss variation of periodontal pocket depth above 8mm teeth before and after the treatment,control change group,minocycline group,RISE-AP12(R) group increased (P ＜0.01),and the difference was statistically significant.Conclusion:The application of antibacterial peptide and minocycline hydrochloride in the treatment of periodontitis with different periodontal pocket depth can achieve better curative effect,and has certain clinical value.