性激素受体在胆囊癌中的表达研究

摘要

Objective　To study the expression of sex hormone receptors in human gallbladder cancer.　 Methods　Using immunohistochemistry avidin biotin peroxidase complex（ABC) method, the expression of estrogen receptor (ER)、 progesterone receptor (PR) and androgen receptor (AR) was examined in paraffin embedded sections of gallbladder cancer in 106 cases and 61 benign controls.　Results　The positive expression rate of ER、 PR and AR in gallbladder cancer was 67%、57% and 44% respectively. The positive rates of sex hormone receptors had significant correlation with pathologic differentiation grade. 　Conclusion　There was significant correlations between sex hormones and the development of gallbladder cancer. Sex hormones might be implicated in the therapy of gallbladder cancer.%目的探讨性激素受体在胆囊癌中的表达。方法采用免疫组织化学Avidin Biotin Peroxidase Complex (ABC)方法对 106例胆囊癌和61例胆囊良性病变石蜡切片标本进行雌激素、孕激素及雄激素受体检测。结果胆囊癌中三种受体阳性率分别为67%、57%、44%。性激素受体阳性率与胆囊癌分化程度有密切关系。结论性激素与胆囊癌发展关系密切。内分泌治疗可能成为治疗胆囊癌的一种方法。