Objective In cases of proximal bile duct cancer, radical en bloc resection of the hepatodudenal ligament is sometimes compulsory.This study was undertaken to evaluate the feasibility of arterialization of the portal vein to restore liver blood flow after the radical resection. Methods Experimental model was established in rats with common bile duct ligation. Operative effect on rats was viewed and alterations of liver function and structure was investigated. Results BIL,ALT,AST and ALP elevated significantly (compared with normal, P＜0.01) on 6 days after common bile duct ligation. BIL became normal (P＞0.05),ALT,AST and ALP fell obviously,but still had significant difference compared with normal (P＜0.05) at one week after bile duct reopening plus arterialization of portal vein, ALT, AST and ALP become normal （compared with normal, P＞0.05） in one month. Liver structure recovered smoothly. Conclusions The method of reconstruction after resection of the hepatodudenal ligament may be applicable for clinical use.%目的 了解用门静脉动脉化重建肝血流的可行性。 方法 建立门静脉动脉化重建肝脏血流的梗阻性黄疸大鼠实验模型，观察肝脏的结构和功能改变。 结果 大鼠胆总管结扎5d后，胆红素（BIL）、转氨酶（ALT、AST）和碱性磷酸酶（ALP）显著增高（与对照组相比，P<0.01），胆总管结扎5d后的大鼠行胆管再通+门静脉动脉化手术后1周，BIL即可恢复正常（与对照组相比，P＞0.05），ALT、AST和ALP明显下降，但差异仍有显著意义（P＜0.05）,手术后1个月即可完全恢复正常（与对照组相比，P＞0.05），肝脏结构亦可顺利恢复。 结论 门静脉动脉化重建肝血流在临床上有一定的可行性和应用前景
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