肝癌根治术前GGT、ALT/AST和术后临床病理特征与预后的关系

摘要

Objective To investigate the relationship between preoperative GGT γ-glutamyl transferase),ALT/AST with clinicopathological features and prognosis after radical surgery of hepatocellular carcinoma(HCC).Methods The clinical data of 187 HCC patients undergoing radical resection in our hospital were retrospectively analyzed.Survival analysis was performed using the Kaplan-Meier analysis method to estimate the survival rate,and Log-rank analysis was used to compare survival rates between groups.Cox proportional hazards model was used for univariate and multivariate survival analysis.Results The Kaplan-Meier curves showed that HCC patients with normal GGT leval and higher ALT/AST ratio had a longer survival time than those with higher GGT leval and those with lower ALT/AST ratio (all P ＜ 0.05).The multivariate analyses showed that GGT leval and TNM staging were independent factors in predicting overall survival time in HCC patients.Conclusions GGT is a predictive index of overall survival of HCC patients.%目的 探讨肝癌根治术前γ-谷氨酰基转移酶(GGT)、丙氨酸转氨酶/天冬氨酸转氨酶比值(ALT/AST)与临床病理特征及预后的关系.方法 回顾性分析在商丘市第一人民医院行根治性切除术的187例HCC患者的临床资料,分别比较GGT、ALT/AST与临床病理特征及总体生存率之间的差异.采用Kaplan-Meier法绘制生存曲线,生存的曲线比较采用Log-rank检验.利用Cox比例风险模型进行单因素及多因素的生存分析.结果 正常γ-GT值组原发性肝癌患者的总生存时间好于高γ-GT值组患者的总生存时间(x2=5.305,P=0.021),高ALT/AST值组的预后优于低ALT/AST值组(x2=5.763,P=0.016),GGT值和TNM分期为影响原发性肝癌患者预后的独立因素.结论 GGT值是影响原发性肝癌患者预后的独立因素.