新疆维吾尔自治区哈萨克族高尿酸血症及代谢综合征患病情况调查

摘要

Objective To study prevalence of metabolic syndrome (MS) , it's components and hyperuricemia (HUA) among Kazakh people in Xinjiang Uighur autonomous region, China. Methods A cross-sectional survey was conducted among Kazakh people aged 35 years and over in seven prefectures of Xinjiang, including Urumqi, Kelamayi (Karamay) , Fukang, Tulufan (Turpan), Hetian (Hotan) , Aletai (Altay) and Yili during October 2007 to March 2010, with a four-stage cluster sampling, the total sample size were 4094. Through the methods of questionnaire survey, physical examination, biochemical examination and so on, to study prevalence of MS in HUA and it's components by blood biochemical examinations. Results A total of 3915 Kazakh adult people, equal number of men and women, were surveyed, with a response rate of 95. 63 percent. Overall prevalence of HUA was 3. 96 percent( 155/3915 ) , 6.02 percent for men and 2. 03 percent for women(114/1894 and 41/2021) , respectively, with statistically significant difference ( P ＜ 0.05 ). Prevalence of MS was 39.47 percent in those with HUA and 22. 53 percent in those without HUA (45/114 and 401/1780), respectively (P ＜ 0.01). Among women, prevalence of MS was 46. 34 percent in those with HUA and 16. 11 percent in those without HUA( 19/41 and 319/1980), respectively (P＜0. 01). Prevalence of high blood pressure, hypertriglyceridemia, lower blood high-density lipoprotein cholesterol (HDL-C) and central obesity were 59.65 percent, 42.11 percent,32.46 percent, 7. 89 percent and 79. 82 percent in those with HUA, respectively, with prevalence of hyperglyceridemia and central obesity significantly higher than in those of non-HUA ( P ＜ 0. 05 ). Among women, prevalence high blood pressure, hypertriglyceridemia, lower blood HDL-C and central obesity were 48.78 percent, 39.02 percent, 41.46 percent, 2.44 percent and 78.05 percent, respectively, in HUA group, with prevalence of hyperglyceridemia, lower blood HDL-cholesterol and central obesity significantly higher than in those of non-HUA ( P ＜ 0. 05 ). Conclusions Prevalence of MS was higher in Kazakh people suffered with HUA than those without HUA, as well as prevalence of components of MS, suggesting that prevention and treatment for HUA is necessary, which can reduce MS and its components in the region.%目的 调查新疆维吾尔自治区哈萨克族高尿酸血症(HUA)和代谢综合征(MS)及各组分患病情况.方法 自2007年10月到2010年3月,应用四阶段整群随机抽样法,将新疆维吾尔自治区抽取乌鲁木齐市、克拉玛依市、阜康市、吐鲁番地区、和田地区、阿勒泰地区和伊犁哈萨克自治州等7个地区年龄＞35岁的哈萨克族4094人作为样本.经问卷调查、体格检查及生化检测等方法,调查其HUA、MS及各组分患病情况.结果 实际完成调查者3915人,应答率95.63%,男女均衡.被调查哈萨克族人群中HUA的总患病率为3.96%(155/3915),其中男性为6.02%(114/1894),女性为2.03%(41/2021),男性患病率明显高于女性(P＜0.05).将总人群分为HUA组和非HUA组,男性HUA组MS的患病率为39.47%(45/114),非HUA组中MS的患病率为22.53%(401/1780),P＜0.01;女性HUA组MS的患病率为46.34%(19/41),非HUA组中MS患病率为16.11%(319/1980),两组比较差异有统计学意义(P＜0.01).男性HUA组中MS的各组分高血压、高甘油三酯血症、低高密度脂蛋白血症、高血糖和中心性肥胖的患病率分别为59.65%、42.11%、32.46%、7.89%和79.82%,其中高甘油三酯血症和中心性肥胖患病率明显高于非HUA组,差异有统计学意义(P＜0.05);在女性HUA组中MS各组分的患病率分别为48.78%、39.02%、41.46%、2.44%和78.05%,其中高甘油三酯血症、低高密度脂蛋白血症和中心性肥胖患病率明显高于非HUA组,差异有统计学意义(P＜0.05).结论 新疆哈萨克族HUA患者中MS的检出率高于非HUA者,且MS各组分患病率也较高.提示对于HUA地域性的预防和治疗可以进一步降低MS及相关组分的患病率.