非侵入性肝脏线粒体功能评估新方法——13C呼气试验

摘要

Mitochondria plays a major role in cell energy metabolism, therefore, mitochondrial dysfunction inevitably participates in the development and progress of liver diseases. Assessment of liver mitochondrial function in vivo could provide insight into specific liver function and the pathogenesis of liver diseases, and will be a helpful tool for establishing diagnosis, assessing therapeutic response and predicting prognosis. 13C breath test with the advantages of noninvasion, high accuracy and real-time measurement, could be used for the assessment of liver mitochondrial function in vivo. This article reviewed the 13C breath test as a noninvasive method for the assessing of liver mitochondrial function.%线粒体在细胞能量代谢中具有重要作用,线粒体功能紊乱与肝病的发生和发展相关.活体内肝脏线粒体功能评估有助于了解特定肝脏功能、探讨肝病的致病机制,是诊断肝病、评估治疗手段和预后的有用工具.13C呼气试验由于其非侵入性,且具有较高的准确性以及独特的实时检测特性,可用于活体内肝脏线粒体功能的评估.本文就此作一综述.