乙型及丙型肝炎病毒感染与原发性肝癌的临床研究

摘要

Objective To investigate the correlation of HBV DNA, HBsAg, HBeAg, HBeAb, HBcAb, anti-HCV with primary liver cancer (PLC). Methods The infection of HBV and HCV among 58 patients with PLC (case group)and 58 patients with other cancers (control group) was analyzed and therelationship of serum HBV markers and HBV DNA with PLCwas investigated by retrospective study. Results The positivera te of HBV in case group was 82. 76％,and the control group 44.83％. There was a significant difference between the two groups (P ＜ 0.05 ). There was no significant difference of the positive rates of HCV and HBV/HCV mixed in two groups (P ＞ 0.05 ) . The positive rates of serum HBV DNA were 72.92％ and 23.08％ (P ＜ 0.05 ) in case group and control group respectively. Positive rates of HBsAg, HBeAb and HBcAb in case group were higher than those in control group (P ＜ 0.05). There was no significant difference of HBeAg between two groups ( P ＞ 0.05 ). Conclusion There was a affinity of HBV infection, including HBVDNA, HBsAg, HBeAg, HBeAb and HBcAb with the development of primary liver cancer.%目的 研究HBV DNA、HBsAg、HBeAg、HBeAb、HBcAb及抗-HCV与原发性肝癌发生的相关性.方法 采用回顾性调查分析方法,对58例原发性肝癌患者(病例组),同期收治的58例其他恶性肿瘤患者(对照组)HBV和HCV感染情况进行统计,并分析HBV血清标志物及HBV DNA与原发性肝癌发生发展的规律.结果 两组资料的HBV感染率分别为82.76%和44.83%,病例组与对照组比较有显著性差异(P＜0.05),单纯HCV感染及HBV/HCV混合感染率两组无明显差异(P＞0.05); 血清HBV DNA阳性率在病例组和对照组分别为72.92%、23.08%(P＜0.05); HBsAg、HBeAb和HBcAb检出率病例组高于对照组(P＜0.05);而HBeAg阳性率两组比较无显著性差异(P＞0.05).结论 在慢性HBV感染的肝癌高发人群中,HBV DNA、HBsAg、HBeAg、HBeAb及HBcAb所反映的HBV感染状态及不同临床演变过程与肝癌的发生发展密切相关,共同参与肝癌的发病机制.