药物性肝病248例临床分析

摘要

Objective To explore the etiology, clinical features and prognosis of drug-induced liver disease (DILD). Methods A retrospective analysis was taken of DILD in hospitalized for medication history, clinical manifestations. Results The causes of DILD were mainly antibiotics (12. 1% ), medicine (23.0% ), anti-TB drugs (8.0% ), anti-cancer drugs (7. 2%), immunosuppressive agents (14..5%). The clinical manifestations were mainly anorexia (62.5%), fatigue (55. 1%), nausea (51.3%), jaundice (37.2%), abdominal pain (18.3%), pruritus (12.9% ), rash (4.6% ). Conclusion Clinicians should pay attention to and strengthen the DILD prevention, diagnosis and treatment.%目的 分析药物性肝病( DILD)的病因、临床特点及预后,提高临床医生对DILD的诊疗水平.方法 采用回顾性分析的方法对248例DILD住院患者的用药史、临床表现以及预后等进行研究.结果 引起DILD的药物以抗生素类药物(12.1％)、中药(23.0％)、抗结核药物(8.0％)、抗肿瘤药物(7.2％)、免疫抑制剂(14.5％)为常见.临床表现以纳差(62.5％)、乏力(55.1％)、恶心(51.3％)、黄疸(37.2％)、腹痛(18.3％)、瘙痒(12.9％)、皮疹(4.6％)等多见；肝性脑病、腹水、凝血酶原时间、黄疸等因素与患者死亡相关.结论 临床医生应重视和加强DILD的预防、诊断和治疗.