Objective To investigate the association between human leucocyte antigen (HLA)-DQBl allelic polymorphism and clinical classification of IBS. Methods 60 patients were investigated for DQB1 gene by DNA microar-ray. The results were compared with those of healthy subjects. Results The frequency of DQB1 * 02 in IBS patients was significantly higher than that in control, the frequency of DQB1 * 0603 in IBS patients was significantly lower than that in control. There was no significant difference in the frequency of HLA-DQB1 among all types of IBS. Conclusion DQB1 * 02 or DQB1 * 0603 may be the susceptihility genes in patients with Chinese Han nationality in Guangdong of IBS, HLA-DQ gene polymorphism with IBS clinical classification closely unrelated.%目的 研究HLA-DQB1等位基因多态性与我国广东籍汉族肠易激综合征(IBS)遗传易感的相关性.方法 应用PCR及基因测序技术分析广东籍汉族IBS患者60例和健康对照者DQB1的基因分型,比较基因位点的发生频率的分布差异.结果 与正常对照组相比,IBS患者DQB1* 02等位基因的频率较低,DQB1*0603的频率较高,DQB1* 0601、DQB1* 0602、DQB1* 0604的频率与正常对照组相比无显著性差异,IBS各临床亚型之间等位基因的频率无明显差异.结论 DQBl* 02或DQB1* 0603等位基因可能是我国广东籍汉族人群IBS的易感基因.HLA-DQ基因多态性与IBS的临床分型无关.
展开▼
