脯氨酰寡肽酶的肝内生物学功能研究进展

摘要

Prolyl oligopeptidase ( POP) is widely distribute in the body and highly activity in the liver. POP affects the functions of inflammatory cells such as Kupffer cells, hepatic stellate cells and hepatocytes in a direct or indirect way, regulates inflammation, extracellular matrix ( ECM) deposition and hepatocyte proliferation, and plays an impor-tant role in liver repair after chronic injury. POP may become a promising target for mechanical study and therapy of pathological liver repair after chronic liver injury. This paper reviews the recent advance in biological function of POP in the liver.%脯氨酰寡肽酶( prolyl oligopeptidase,POP)体内分布广泛,肝内活性较高。 POP通过直接或间接作用,影响Kupffer细胞等炎性细胞、肝细胞和肝星状细胞功能,调控肝内炎症、肝细胞增殖和细胞外基质( extracellular matrix, ECM)沉积,在肝脏损伤修复中发挥重要作用,可能成为慢性肝损伤修复机制研究及治疗的新切入点。本文就POP的肝内生物学功能作一概述。