以肠道菌群为靶点治疗肠易激综合征的研究进展

摘要

Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder with unclear pathogenesis.It is characterized by abdominal pain and change of bowel evacuation habits.Studies have shown that intestinal flora disorder acts an important role of its pathogenesis.Symptoms can be alleviated by fecal microbiota transplantation, adding probiotics, aijiu therapy and obliterating Helicobacter pylori.This article reviewed the progress of the treatments of IBS by modulating intestinal flora.%肠易激综合征(irritable bowel syndrome,IBS)是一种病因不明的功能性肠病,主要表现为腹痛和排便习惯的改变.肠道菌群紊乱是IBS的重要发病原因之一,通过粪菌移植(fecal microbiota transplantation,FMT)、补充益生菌、艾灸刺激调节肠道菌群和根除幽门螺杆菌(Helicobacter pylori,H.pylori)均能对IBS的症状起到缓解作用.本文就IBS、肠道菌群紊乱和以肠道菌群为靶点治疗IBS的研究进展作一概述.