目的：探讨复方甘草酸苷联合双环醇在治疗抗结核药物性肝炎中的作用。方法选择结核病治疗中发生药物性肝炎并停用抗结核治疗药物的患者72例，随机分为治疗组36例（常规治疗＋复方甘草酸苷＋双环醇：复方甘草酸苷注射液60 ml＋5%葡萄糖注射液250 ml，静脉滴注，每日1次；双环醇片25 mg，口服，每日3次）和对照组36例（常规治疗组，即进行常规护肝药物治疗），4周为1个疗程；对两组患者肝损害情况[丙氨酸转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（T-BIL）]及预后进行观察比较。结果两组患者症状、体征的恢复无明显差异（P＞0.05）。治疗组显效及有效36例（100.0%），对照组显效及有效27例（75%），治疗组肝功能损害恢复情况优于对照组，两组差异显著（P＜0.05）。结论在对结核患者进行抗结核治疗过程中，应加强肝功能监测；复方甘草酸苷联合双环醇治疗抗结核药物引起的药物性肝炎疗效显著。%Objective To investigate the effect of compound glycyrrhizin with bicyclol in the treatment of drug-induced liver injury (DILI) which induced by anti-tuberculotic (anti-TB). Methods Seventy-two DILI patients were randomly divided into the treatment group (36 patients:conventional treatment+compound glycyrrhizin +bicyclol) and control group (36 patients:conventional therapy), 4-weeks treatment was one course. Then observed and compared the compared the damage (ALT, AST and T-BIL) and prognosis of two groups. Results There was no signiifcant difference in both of symptoms and recovery signs in two groups (P > 0.05). All the patients (100.0%) in treatment group and 27 patients (75%) in the control group had the signiifcant effect, and the liver recovery of treatment group was better than the control group, the difference was signiifcant (P < 0.05). Conclusion For the patients with DILI, monitoring of liver function should be strengthened, and compound glycyrrhizin with bicyclol treatment could caused a signiifcant effect in DILI.
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