氟比洛芬酯超前镇痛预防肺叶切除术全身麻醉苏醒期躁动的临床观察

摘要

Objective To discuss the clinical effects and safety of lfurbiprofen preemptive analgesia to prevent general anesthesia emergence agitation of lobectomy. Method 60 cases of patients underwent lobectomy were randomly divided into observation group and control group, 30 cases in each group, all underwent conventional induction anesthesia, surgery patients were given remifentanil, propofol, vecuronium infusion to maintain anesthesia, observation group patients before 30 minutes disposable intravenous injection of lfurbiprofen 1 mg/kg, patients in control group intravenous injection of 5 ml of physiological saline. Two groups of patients were observed with restless score, bleeding time, extubation time, the time of anesthesia and the incidence of adverse reactions. Result Observation group patients restlessness score was (0.88±0.34) points, signiifcantly lower than that of control group [(1.89±0.53) points], the difference was signiifcant (P0.05). Observation group after operation dizziness headache was 3 cases (10%), nausea and vomiting was 9 cases (30.00%), chills and fever was 1 case (3.33%), heart palpitations was 3 cases (10%), somnolence was 2 cases (6.67%), control group of patients with dizziness headache was 5 cases (16.67%), nausea and vomiting was 11 cases (36.67%), chills and fever was 2 cases (6.67%), heart palpitations was 1 case (3.33%), somnolence was 4 cases (13.33%), the incidence of adverse reactions in two groups were not signiifcant (P > 0.05). Conclusion Flurbiprofen injection for prevention of general anesthesia emergence agitation of lobectomy is effective, and does not increase the adverse reaction of patients, worthy of clinical application.%目的：探讨氟比洛芬酯超前镇痛预防肺叶切除术全身麻醉苏醒期躁动的临床效果及安全性。方法将60例肺叶切除术患者随机分为观察组和对照组，每组各30例，均行常规诱导全身麻醉气管插管，术中给予患者瑞芬太尼、丙泊酚、维库溴铵泵注维持麻醉。观察组患者术前30分钟一次性静脉注射氟比洛芬酯1 mg/kg，对照组患者静脉注射5 ml生理盐水。观察两组患者苏醒期躁动评分、出血时间、拔管时间、麻醉时间及不良反应发生率。结果观察组患者苏醒期躁动评分为（0.88±0.34）分，明显低于对照组[（1.89±0.53）分]，差异具有显著性（P＜0.05）；两组患者麻醉时间、出血时间、拔管时间比较差异均无显著性（P＞0.05）；观察组患者术后头晕头痛3例（10.00%）、恶心呕吐9例（30.00%）、畏寒发热1例（3.33%）、心悸3例（10.00%）、嗜睡2例（6.67%），对照组患者头晕头痛5例（16.67%）、恶心呕吐11例（36.67%）、畏寒发热2例（6.67%）、心悸1例（3.33%）、嗜睡4例（13.33%），两组患者不良反应发生率比较差异均无显著性（P＞0.05）。结论氟比洛芬酯超前镇痛预防肺叶切除术全身麻醉苏醒期躁动效果明显，且不增加患者不良反应，值得临床推广应用。