目的：比较吡啶斯的明与左旋多巴单日复合与两日序贯激发生长激素对儿童矮小症的诊断价值。方法选择本院2012年5月至2013年5月收治的矮小症患儿40例，将其随机均分为单日复合组与两日序贯组，对两种治疗方法激发生长激素分泌的峰值（激发试验后任一次测得的生长激素最高值为峰值）以及阳性率（生长激素峰值＞10 ng/ml为阳性）进行比较。结果单日复合组患儿生长激素峰值为（16.44±6.96）ng/ml，阳性率为80%，均明显高于两日序贯组[（14.12±6.32）ng/ml，60%]，差异具有显著性（P＜0.05）。结论吡啶斯的明与左旋多巴单日复合能够有效激发生长激素分泌，对治疗儿童矮小症更为有效。%Objective To compare the diagnostic value of pyridostigmine with levodopa in a single day and two-day composite sequential to stimulate growth hormone among children with short stature. Method 40 children with short stature in our hospital from May 2012 to May 2013 were selected, randomly divided into two groups, 20 cases in single-day composite group and the other 20 cases in two-day sequential group. Then the growth hormone secretion peak (growth hormone stimulation test, served as a measured maximum value of the peak), and the positive rate (GH peak>10 ng/ml as positive) in two groups after different stimulate method were compared. Result Peak of growth hormone in single-day composite group was (16.44±6.96) ng/ml, the positive rate was 80%, signiifcantly higher than the two-day sequential group, with peak of growth hormone (14.12±6.32) ng/ml, and positive rate was 60%, the difference was statistically signiifcant (P<0.05). Conclusion Single day with levodopa composite pyridostigmine is more effective for stimulating growth hormone secretion, more effective treatment for children with short stature.
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