沙格列汀联合甘精胰岛素治疗老年2型糖尿病的有效性和安全性研究

摘要

ObjectiveTo observe the effectiveness and safety of saxagliptin combined with insulin glargine in the treatment of gerontal patients with type 2 diabetes mellitus.Method60 gerontal patients who were injected insulin glargine or combined with metformin and whose blood glucose were poor controled with HbA1c 8%~11%, were divided into treatment group and control group. Treatment group patients were received saxagliptin combined with insulin glargine (Sax+Gla), control group were received acarbose combined with insulin glargine (Aca+Gla). FBG, 2hBG, HbA1c, insulin dose, adverse reaction were compared before and after the treatment between the two groups.Result24 weeeks after the treatment, FBG、2hBG、HbA1c of the two groups decreased signiifcantly (P<0.05). The incidence of hypoglycemia and other adverse effects were similar (P>0.05). The insulin dose and weight increase in treatment group were lower than control group (P<0.05).ConclusionSaxagliptin combined with insulin glargine is effective and safe for gerontal patients with type 2 diabetes mellitus.%目的：观察沙格列汀联合甘精胰岛素治疗老年2型糖尿病的有效性和安全性。方法将60例年龄≥60岁、糖化血红蛋白（HbA1c）为8%～11%、单独使用甘精胰岛素或联合口服二甲双胍血糖控制欠佳的老年2型糖尿病患者随机分为观察组和对照组。观察组患者给予沙格列汀＋甘精胰岛素（Sax＋Gla）治疗，对照组患者给予阿卡波糖＋甘精胰岛素（Aca＋Gla）治疗，观察两组患者治疗前后空腹血糖（FBG）、餐后2小时血糖（2hBG）、HbA1c、胰岛素用量及不良反应发生情况。结果治疗后24周，两组患者FBG、2hBG、HbA1c水平均较基线水平降低（P＜0.05），低血糖和其他不良反应发生率比较均无显著差异（P＞0.05）。观察组患者胰岛素用量和体重增加明显低于对照组（P＜0.05）。结论沙格列汀联合甘精胰岛素可明显改善老年2型糖尿病患者的血糖水平，且具有较好的安全性。