丙戊酸钠治疗小儿慢性癫痫的有效性和安全性分析

摘要

ObjectiveTo observe the clinical efifciency and security of sodium valproate in the treatment of chronic epilepsy children.MethodSelected 114 children with chronic epilepsy treated in our hospital from March 2013 to June 2014 as research objects, they were randomly divided into observation group (58 cases) and control group (56 cases). Children in observation group were treated with sodium valproate, control group were treated with carbamazepine. The curative effect and adverse reactions of the two groups were compared. ResultThe total efifciency of in observation group was higher than control group (χ2=4.8181,P<0.05). The incidence of adverse reaction in observation group was lower than control group (χ2=4.3572,P<0.05). ConclusionClinical efifciency and security of sodium valproate in the treatment of chronic epilepsy children are better than carbamazepine. It is worthy of clinical promotion.%目的：分析丙戊酸钠治疗小儿慢性癫痫的临床有效性和安全性。方法选取本院2013年3月至2014年6月收治的114例慢性癫痫患儿为研究对象，将其随机分为观察组（58例）与对照组（56例），观察组患儿给予丙戊酸钠治疗，对照组患儿给予卡马西平治疗。观察并比较两组患儿的治疗效果及不良反应发生情况。结果观察组患儿治疗总有效率高于对照组（χ2＝4.8181，P＜0.05），不良反应发生率低于对照组（χ2＝4.3572，P＜0.05）。结论丙戊酸钠治疗小儿慢性癫痫的临床效果明显优于卡马西平，且无严重不良反应，是目前较为理想的防治小儿慢性癫痫的药物，值得临床推广。