中老年人群微量白蛋白尿患病率及相关危险因素研究

摘要

ObjectiveTo investigate the prevalence of microalbuminuria (MAU) and its related factors in middle-aged and elderly population.Method1086 subjects were recruited. Health questionnairs and related laboratory indexes were investigated by cluster random sampling. Urine albumin to creatinine ratio (ACR) was used to screen for MAU. The data were analyzed with multivariate Logistic regression analysis to explore the related factors for MAU.ResultThe overall prevalence of MAU in middle-aged and elderly population was 12.80%(139/1086), with male as 12.18% (119/977) and female as 18.35% (20/109) (P>0.05). The independent risk factors of MAU in men were age (OR=1.038), fasting blood-glucose (OR=1.533), waist circumference (OR=1.033).ConclusionThe monitoring of related risk factors should be enhanced in middle-aged and elderly population. Intervention should be carried out as early as possible to delay the process of kidney disease.%目的：调查中老年人群微量白蛋白尿（microalbuminuria，MAU）的患病率，探讨MAU的相关危险因素。方法2013年4月采取随机整群抽样方法对本院体检的1086例中老年人进行健康问卷调查和实验室相关指标检测，测定受试者尿白蛋白/肌酐比值（albuminuria to creatinine ratio，ACR）。统计调查人群中MAU患病率，对可能影响ACR的相关因素进行回归分析。结果受检者中MAU检出率为12.80%（139/1086），其中，男性检出率为12.18%（119/977），女性检出率为18.35%（20/109），二者比较无显著差异（P＞0.05）。男性受检者Logistic回归分析显示，年龄（OR＝1.038）、空腹血糖（OR＝1.533）、腰围（OR＝1.033）是MAU的独立危险因素。结论应加强对中老年人群相关危险因素的监测，尽早干预，延缓肾脏病进展。